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Autotolerant cerulo...
Autotolerant ceruloplasmin based biocathodes for implanted biological power sources
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- Aleksejeva, Olga (författare)
- Malmö universitet,Institutionen för biomedicinsk vetenskap (BMV)
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- Sokolov, A. V. (författare)
- Russia Saint-Petersburg State University, Russia
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- Marquez, I. (författare)
- University of Seville, Spain
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- Gustafsson, Anna (författare)
- Malmö universitet,Institutionen för biomedicinsk vetenskap (BMV)
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- Bushnev, S. (författare)
- Russian Academy of Sciences, Russia
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- Eriksson, Håkan (författare)
- Malmö universitet,Institutionen för biomedicinsk vetenskap (BMV)
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- Ljunggren, Lennart (författare)
- Malmö universitet,Institutionen för biomedicinsk vetenskap (BMV)
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- Shleev, Sergey (författare)
- Malmö universitet,Institutionen för biomedicinsk vetenskap (BMV),Russian Academy of Sciences, Russia
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(creator_code:org_t)
- Elsevier, 2021
- 2021
- Engelska.
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Ingår i: Bioelectrochemistry. - : Elsevier. - 1567-5394 .- 1878-562X. ; 140
- Relaterad länk:
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https://doi.org/10.1...
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https://mau.diva-por... (primary) (Raw object)
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https://doi.org/10.1...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- High-performance autotolerant bioelectrodes should be ideally suited to design implantable bioelectronic devices. Because of its high redox potential and ability to reduce oxygen directly to water, human ceruloplasmin, HCp, the only blue multicopper oxidase present in human plasma, appears to be the ultimate biocatalyst for oxygen biosensors and also biocathodes in biological power sources. In comparison to fungal and plant blue multicopper oxidases, e.g. Myrothecium verrucaria bilirubin oxidase and Rhus vernicifera laccase, respectively, the inflammatory response to HCp in human blood is significantly reduced. Partial purification of HCp allowed to preserve the native conformation of the enzyme and its biocatalytic activity. Therefore, electrochemical studies were carried out with the partially purified enzyme immobilised on nanostructured graphite electrodes at physiological pH and temperature. Amperometric investigations revealed low reductive current densities, i.e. about 1.65 µA cm−2 in oxygenated electrolyte and in the absence of any mediator, demonstrating nevertheless direct electron transfer based O2 bioelectroreduction by HCp for the first time. The reductive current density obtained in the mediated system was about 12 µA cm−2. Even though the inflammatory response of HCp is diminished in human blood, inadequate bioelectrocatalytic performance hinders its use as a cathodic bioelement in a biofuel cell.
Ämnesord
- NATURVETENSKAP -- Kemi -- Analytisk kemi (hsv//swe)
- NATURAL SCIENCES -- Chemical Sciences -- Analytical Chemistry (hsv//eng)
Nyckelord
- Biological fuel cells; Blood; Electrolytes; Electron transport properties; Enzyme activity; Enzyme electrodes; Oxygen; pH; Purification; Redox reactions
- Biocatalytic activity; Bioelectronic device; Direct electron transfer; Electrochemical studies; Inflammatory response; Nanostructured graphite; Native conformation; Partial purification
- Graphite electrodes
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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