Antimicrobial Potential of Strontium Functionalized Titanium Against Bacteria Associated with Periimplantitis.

• Aim: to explore the antimicrobial potential of strontium (Sr) coated wafers against multiple bacteria associated with per-implant infections, in both mono and multi-species forms.Materials and methods: Sr-coated and uncoated Ti wafers were tested for bactericidal effect and biofilm growth inhibition against several bacteria, either grown as a mono-species or as a culture of multi-species, using bacterial viability assay and plate counting method. Mono-species test performed over a rocking platform and evaluated after 2 and 24 hours, while multi-species antimicrobial test evaluation was carried out at day 1, 3 and 6. The impact of Sr coating on the total percentage of P. gingivalis in the multi-species biofilm, using qPCR, and gingipain activity were also assessed.Results: Sr-coated wafers were associated with statistically significant less viable cells for both mono- and multi-species tests compared to Ti controls. Number of colony forming units (CFUs) were significantly higher in Ti wafers, for S. aureus, at all time-points of evaluation and at day 1 for E. coli within the biofilm compared to Sr-coated wafers. Gingipains activity were higher in Ti wafers compared to Sr-coated ones, and qPCR showed that P. gingivalis percentage was 15% of the total biofilm of Ti wafers at day 6, while it remained below detection levels at Sr-coated wafers.Conclusion: Sr coating displayed promising antimicrobial potential against bacteria associated with peri-implantitis grown either as mono-species or in a multi-species consortium.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Odontologi (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Dentistry (hsv//eng)

Nyckelord

Strontium

dental implant

titanium

peri-implantitis

antimicrobial coatings.

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