Streptococcus Species Abundance in the Gut Is Linked to Subclinical Coronary Atherosclerosis in 8973 Participants From the SCAPIS Cohort

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Streptococcus Species Abundance in the Gut Is Linked to Subclinical Coronary Atherosclerosis in 8973 Participants From the SCAPIS Cohort

Sayols-Baixeras, Sergi (författare): Molecular Epidemiology and Science for Life Laboratory, Department of Medical Sciences, Uppsala University, Sweden; CIBER Cardiovascular Diseases (CIBERCV), Instituto de Salud Carlos III, Madrid, Spain

Dekkers, Koen F. (författare): Molecular Epidemiology and Science for Life Laboratory, Department of Medical Sciences, Uppsala University, Sweden

Baldanzi, Gabriel (författare): Molecular Epidemiology and Science for Life Laboratory, Department of Medical Sciences, Uppsala University, Sweden

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Jönsson, Daniel (författare): Malmö universitet,Odontologiska fakulteten (OD),Department of Clinical Sciences in Malmö, Lund University, Sweden; Public Dental Service of Skåne, Lund, Sweden

Hammar, Ulf (författare): Molecular Epidemiology and Science for Life Laboratory, Department of Medical Sciences, Uppsala University, Sweden; Department of Clinical Sciences in Malmö, Lund University, Sweden

Lin, Yi-Ting (författare): Molecular Epidemiology and Science for Life Laboratory, Department of Medical Sciences, Uppsala University, Sweden; Division of Family Medicine and Primary Care, Department of Neurobiology, Care Science and Society, Karolinska Institutet, Huddinge, Sweden

Ahmad, Shafqat (författare): Molecular Epidemiology and Science for Life Laboratory, Department of Medical Sciences, Uppsala University, Sweden; Preventive Medicine Division, Harvard Medical School, Brigham and Women’s Hospital, Boston, MA

Nguyen, Diem (författare): Molecular Epidemiology and Science for Life Laboratory, Department of Medical Sciences, Uppsala University, Sweden

Varotsis, Georgios (författare): Molecular Epidemiology and Science for Life Laboratory, Department of Medical Sciences, Uppsala University, Sweden

Pita, Sara (författare): Clinical Microbiomics A/S, Copenhagen, Denmark; The Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, Lyngby, Denmark

Nielsen, Nynne (författare): Clinical Microbiomics A/S, Copenhagen, Denmark

Eklund, Aron C. (författare): Clinical Microbiomics A/S, Copenhagen, Denmark

Holm, Jacob B. (författare): Clinical Microbiomics A/S, Copenhagen, Denmark

Nielsen, H. Bjørn (författare): Clinical Microbiomics A/S, Copenhagen, Denmark

Ericson, Ulrika (författare): Department of Clinical Sciences in Malmö, Lund University, Sweden

Brunkwall, Louise (författare): Department of Clinical Sciences in Malmö, Lund University, Sweden; Clinical Studies Sweden, Forum Söder, Region Skåne, Lund, Sweden

Ottosson, Filip (författare): Department of Clinical Sciences in Malmö, Lund University, Sweden; Section for Clinical Mass Spectrometry, Danish Center for Neonatal Screening, Department of Congenital Disorders, Statens Serum Institut, Copenhagen, Denmark

Larsson, Anna (författare): Department of Clinical Sciences in Malmö, Lund University, Sweden

Ericson, Dan, 1953- (författare): Malmö universitet,Odontologiska fakulteten (OD)

Klinge, Björn (författare): Malmö universitet,Odontologiska fakulteten (OD),Department of Dental Medicine, Karolinska Institutet, Solna, Sweden

Nilsson, Peter M. (författare): Department of Clinical Sciences in Malmö, Lund University, Sweden; Department of Internal Medicine, Skåne University Hospital, Malmö, Sweden

Malinovschi, Andrei (författare): Clinical Physiology, Department of Medical Sciences, Uppsala University, Sweden

Lind, Lars (författare): Clinical Epidemiology, Department of Medical Sciences, Uppsala University, Sweden

Bergström, Göran (författare): Department of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Sweden; Department of Clinical Physiology, Sahlgrenska University Hospital, Region Västra Götaland, Gothenburg, Sweden

Sundström, Johan (författare): Clinical Epidemiology, Department of Medical Sciences, Uppsala University, Sweden; The George Institute for Global Health, University of New South Wales, Sydney, Australia

Ärnlöv, Johan (författare): Division of Family Medicine and Primary Care, Department of Neurobiology, Care Science and Society, Karolinska Institutet, Huddinge, Sweden; School of Health and Social Studies, Dalarna University, Falun, Sweden

Engström, Gunnar (författare): Department of Clinical Sciences in Malmö, Lund University, Sweden

Smith, J. Gustav (författare): The Wallenberg Laboratory/Department of Molecular and Clinical Medicine, Institute of Medicine, Gothenburg University, Sweden

Orho-Melander, Marju (författare): Department of Clinical Sciences in Malmö, Lund University, Sweden

Fall, Tove (författare): Molecular Epidemiology and Science for Life Laboratory, Department of Medical Sciences, Uppsala University, Sweden

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(creator_code:org_t)

American Heart Association, 2023
2023
Engelska.
Ingår i: Circulation. - : American Heart Association. - 0009-7322 .- 1524-4539. ; 148:6, s. 459-472

Relaterad länk:: https://doi.org/10.1...; visa fler...; https://mau.diva-por... (primary) (Raw object); https://urn.kb.se/re...; https://doi.org/10.1...; visa färre...

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BACKGROUND: Gut microbiota have been implicated in atherosclerotic disease, but their relation with subclinical coronary atherosclerosis is unclear. This study aimed to identify associations between the gut microbiome and computed tomography–based measures of coronary atherosclerosis and to explore relevant clinical correlates.METHODS: We conducted a cross-sectional study of 8973 participants (50 to 65 years of age) without overt atherosclerotic disease from the population-based SCAPIS (Swedish Cardiopulmonary Bioimage Study). Coronary atherosclerosis was measured using coronary artery calcium score and coronary computed tomography angiography. Gut microbiota species abundance and functional potential were assessed with shotgun metagenomics sequencing of fecal samples, and associations with coronary atherosclerosis were evaluated with multivariable regression models adjusted for cardiovascular risk factors. Associated species were evaluated for association with inflammatory markers, metabolites, and corresponding species in saliva.RESULTS: The mean age of the study sample was 57.4 years, and 53.7% were female. Coronary artery calcification was detected in 40.3%, and 5.4% had at least 1 stenosis with >50% occlusion. Sixty-four species were associated with coronary artery calcium score independent of cardiovascular risk factors, with the strongest associations observed for Streptococcus anginosus and Streptococcus oralis subsp oralis (P<1×10–5). Associations were largely similar across coronary computed tomography angiography–based measurements. Out of the 64 species, 19 species, including streptococci and other species commonly found in the oral cavity, were associated with high-sensitivity C-reactive protein plasma concentrations, and 16 with neutrophil counts. Gut microbial species that are commonly found in the oral cavity were negatively associated with plasma indole propionate and positively associated with plasma secondary bile acids and imidazole propionate. Five species, including 3 streptococci, correlated with the same species in saliva and were associated with worse dental health in the Malmö Offspring Dental Study. Microbial functional potential of dissimilatory nitrate reduction, anaerobic fatty acid β-oxidation, and amino acid degradation were associated with coronary artery calcium score.CONCLUSIONS: This study provides evidence of an association of a gut microbiota composition characterized by increased abundance of Streptococcus spp and other species commonly found in the oral cavity with coronary atherosclerosis and systemic inflammation markers. Further longitudinal and experimental studies are warranted to explore the potential implications of a bacterial component in atherogenesis.

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Streptococcus Species Abundance in the Gut Is Linked to Subclinical Coronary Atherosclerosis in 8973 Participants From the SCAPIS Cohort

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