Bone formation after implantation of autolysed antigen extracted allogeneic bone in ovariectomized rabbits.

• This study was undertaken to evaluate the bone formation response to AAA bone in healthy and oestrogen deficient animals. Seventeen young healthy New Zealand female rabbits were used. Nine rabbits were subjected to ovariectomy and the remaining eight were sham-operated. Four weeks after ovariectomy standardized round cavities, 5mm in diameter, were made medially in the cortical part of each proximal tibia. To half of the cavities autolysed antigen-extracted al-logeneic AAA bone granules were added. After another 8 weeks the animals were sacrificed and sections of the tibial experimental areas were obtained. These were studied in light microscopy and the bone and non-bone areas were measured with computer support.The study showed that the addition of a bone inductive substance such as AAA bone enhances bone formation also in oestrogen deficient animals.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Odontologi (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Dentistry (hsv//eng)

Nyckelord

bone formation

AAA bone

bone defect

osteoporosis

ovariectomy

Medicine

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