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Sökning: id:"swepub:oai:DiVA.org:mau-934" > Twenty years of ena...

Twenty years of enamel matrix derivative : the past, the present and the future

Miron, Richard J. (författare)
Department of Periodontology, Nova Southeastern University, Fort Lauderdale, Florida, USA; Department of Periodontology, University of Bern, Bern, Switzerland
Sculean, Anton (författare)
Department of Periodontology, University of Bern, Bern, Switzerland
Cochran, David L (författare)
Department of Periodontics, Dental School, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA
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Froum, Stuart (författare)
Department of Periodontology and Implant Dentistry, College of Dentistry, New York University, New York, NY, USA
Zucchelli, Giovanni (författare)
Department of Biomedical and Neuromotor Sciences, University of Bologna, Bologna, Italy
Nemcovsky, Carlos (författare)
Department of Periodontology and Dental Implantology, Dental School, Tel-Aviv University, Tel-Aviv, Israel
Donos, Nikos (författare)
Department of Periodontology, Queen Marry University of London, London, UK
Lyngstadaas, Staale Petter (författare)
Department of Biomaterials, Faculty of Dentistry, University of Oslo, Oslo, Norway
Deschner, James (författare)
Section of Experimental Dento-Maxillo-Facial Medicine, University of Bonn, Bonn, Germany
Dard, Michel (författare)
New York University, College of Dentistry, New York, NY, USA
Stavropoulos, Andreas (författare)
Malmö högskola,Odontologiska fakulteten (OD)
Zhang, Yufeng (författare)
Department of Oral Implantology, Wuhan University, Wuhan, China
Trombelli, Leonardo (författare)
Department of Periodotology, Research Centre for the Study of Periodontal and Peri-implant Diseases, University of Ferrara, Ferrara, Italy
Kasaj, Adrian (författare)
Department of Operative Dentistry and Periodontology, University Medical Center, Mainz, Germany
Shirakata, Yoshinori (författare)
Department of Periodontology, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan
Cortellini, Pierpaolo (författare)
Accademia Toscana di Ricerca Odontostomatologica, Firenze, Italy
Tonetti, Maurizio (författare)
European Research Group on Periodontology (ERGOPerio), Genova, Italy
Rasperini, Giulio (författare)
Department of Biomedical, Surgical and Dental Sciences, University of Milan, Milan, Italy; Foundation IRCCS Ca' Granda Polyclinic, Milan, Italy
Jepsen, Søren (författare)
Department of Periodontology, Operative and Preventive Dentistry, University of Bonn, Bonn, Germany
Bosshardt, Dieter D (författare)
Department of Periodontology, University of Bern, Bern, Switzerland
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 (creator_code:org_t)
2016-05-28
2016
Engelska.
Ingår i: Journal of Clinical Periodontology. - : Blackwell Munksgaard. - 0303-6979 .- 1600-051X. ; 43:8, s. 668-683
Relaterad länk:
https://urn.kb.se/re...
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https://doi.org/10.1...
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  • Forskningsöversikt (refereegranskat)
Abstract Ämnesord
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  • Background On June 5th, 2015 at Europerio 8, a group of leading experts were gathered to discuss what has now been 20years of documented evidence supporting the clinical use of enamel matrix derivative (EMD). Original experiments led by Lars Hammarstrom demonstrated that enamel matrix proteins could serve as key regenerative proteins capable of promoting periodontal regeneration including new cementum, with functionally oriented inserting new periodontal ligament fibres, and new alveolar bone formation. This pioneering work and vision by Lars Hammarstrom has paved the way to an enormous amount of publications related to its biological basis and clinical use. Twenty years later, it is clear that all these studies have greatly contributed to our understanding of how biologics can act as mediators for periodontal regeneration and have provided additional clinical means to support tissue regeneration of the periodontium. Aims This review article aims to: (1) provide the biological background necessary to understand the rational for the use of EMD for periodontal regeneration, (2) present animal and human histological evidence of periodontal regeneration following EMD application, (3) provide clinically relevant indications for the use of EMD and (4) discuss future avenues of research including key early findings leading to the development of Osteogain, a new carrier system for EMD specifically developed with better protein adsorption to bone grafting materials

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Odontologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Dentistry (hsv//eng)

Nyckelord

EMD
Emdogain
enamel matrix derivative
enamel matrix proteins
intrabony defect
Osteogain
periodontal regeneration

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