Sökning: id:"swepub:oai:DiVA.org:mdh-36583" >
Prediction of high ...
Prediction of high centrality nodes from reverse-engineered transcriptional regulator networks
-
- Weishaupt, Holger (författare)
- Mälardalens högskola,Utbildningsvetenskap och Matematik,Uppsala University, Sweden,MAM
-
Johansson, Patrik (författare)
-
- Engström, Christopher, 1987- (författare)
- Mälardalens högskola,Utbildningsvetenskap och Matematik,MAM
-
visa fler...
-
Nelander, Sven (författare)
-
- Silvestrov, Sergei, 1970- (författare)
- Mälardalens högskola,Utbildningsvetenskap och Matematik,MAM
-
Swartling, Fredrik J. (författare)
-
visa färre...
-
(creator_code:org_t)
- 2016
- 2016
- Engelska.
-
Ingår i: Proocedings of the 4th Stochastic Modeling Techniques and Data Analysis International Conference with Demographics Workshop. ; , s. 517-531
- Relaterad länk:
-
https://urn.kb.se/re...
Abstract
Ämnesord
Stäng
- The prioritization of genes based on their centrality in biological networkshas emerged as a promising technique for the prediction of phenotype related genes.A number of methods have been developed to derive one such type of network, i.e.transcriptional regulatory networks, from expression data. In order to reliably prioritizegenes from such networks, it is crucial to investigate how well the inferencemethods reconstruct the centralities that exist in the true biological system. We haverecently reported that the correlation of centrality rankings between reference andinferred networks is only modest when using an unbiased inference approach. In thisstudy we extend on these results and demonstrate that the correlation remains modestalso when using a biased inference utilizing a priori information about transcriptionfactors. However, we show further that despite this lack of a strong correlation, theinferred networks still allow a signicant prediction of genes with high centralities inthe reference networks.
Ämnesord
- NATURVETENSKAP -- Data- och informationsvetenskap -- Bioinformatik (hsv//swe)
- NATURAL SCIENCES -- Computer and Information Sciences -- Bioinformatics (hsv//eng)
- NATURVETENSKAP -- Matematik -- Sannolikhetsteori och statistik (hsv//swe)
- NATURAL SCIENCES -- Mathematics -- Probability Theory and Statistics (hsv//eng)
Nyckelord
- Transcriptional network inference
- network inference
- graph centrality
- degree
- betweenness.
- Mathematics/Applied Mathematics
- matematik/tillämpad matematik
Publikations- och innehållstyp
- ref (ämneskategori)
- kon (ämneskategori)