Stereoselective esterification of 2,6-dimethyl-1,7-heptanedioic acid, catalysed by Candida rugosa lipase

• The immobilised Candida rugosa lipase (CRL) displayed S-preference for both stereogenic centres in this sequential esterification of 2,6-dimethyl-1,7-heptanedioic acid (1) (pure meso and meso: (+/-) mixture, 53/47) with n-butanol in cyclohexane at a(w) = 0.8. The reaction was faster when short-chain primary n-alcohols was used and very slow, or even none reactive, when a Ion-chain alcohol was used.

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NATURVETENSKAP  -- Kemi (hsv//swe)

NATURAL SCIENCES  -- Chemical Sciences (hsv//eng)

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organic chemistry

Chemistry

Kemi

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