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Tear Fluid SIgA as ...
Tear Fluid SIgA as a Noninvasive Biomarker of Mucosal Immunity and Common Cold Risk
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- Hanstock, Helen, 1989- (författare)
- Bangor University, UK,Extremes Research Group, Bangor University
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- Walsh, Neil P (författare)
- Bangor University, UK
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- Edwards, Jason P (författare)
- Bangor University, UK
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- Fortes, Matthew B (författare)
- Bangor University, UK
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- Cosby, Sarah L (författare)
- Queen’s University Belfast, Northern Ireland, UK
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- Nugent, Aaron (författare)
- Queen’s University Belfast, Northern Ireland, UK
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- Curran, Tanya (författare)
- Royal Victoria Hospital, Belfast, UK
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- Coyle, Peter V (författare)
- Royal Victoria Hospital, Belfast, UK
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- Ward, Mark D (författare)
- Bangor University, UK
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- Aw Yong, Xin Hui (författare)
- Bangor University, UK
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(creator_code:org_t)
- 2016
- 2016
- Engelska.
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Ingår i: Medicine & Science in Sports & Exercise. - 0195-9131 .- 1530-0315. ; 48:3, s. 569-577
- Relaterad länk:
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https://doi.org/10.1...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
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- Purpose: Research has not convincingly demonstrated the utility of saliva secretory Immunoglobulin-A (SIgA) as a biomarker of upper-respiratory-tract-infection (URTI) risk and disagreement exists about the influence of heavy exercise ('open-window-theory') and dehydration on saliva SIgA. Prompted by the search for viable alternatives, we compared the utility of tear and saliva SIgA to predict URTI prospectively (study-one) and assessed the influence of exercise (study-two) and dehydration (study-three) using a repeated-measures-crossover design.Methods: In study-one, forty subjects were recruited during the common-cold season. Subjects provided tear and saliva samples weekly and recorded upper-respiratory-symptoms (URS) daily for 3-weeks. RT-PCR confirmed common-cold pathogens in 9 of 11 subjects reporting URS (82%). Predictive utility of tear and saliva SIgA was explored by comparing healthy samples with those collected the week pre-URS. In study-two, thirteen subjects performed a 2-hour run at 65% VO2peak. In study-three, thirteen subjects performed exercise-heat-stress to 3% body-mass-loss followed by overnight fluid restriction.Results: Tear SIgA concentration and secretion rate were 48% and 51% lower respectively during URTI and 34% and 46% lower the week pre-URS (P<0.05) but saliva SIgA remained unchanged. URS risk the following week increased 9-fold (95% CI: 1.7 to 48) when tear SIgA secretion rate <5.5 μg[BULLET OPERATOR]min and 6-fold (95% CI: 1.2 to 29) when tear SIgA secretion rate decreased >30%. Tear SIgA secretion rate >5.5 μg[BULLET OPERATOR]min or no decrease >30% predicted subjects free of URS in >80% of cases. Tear SIgA concentration decreased post-exercise (-57%: P<0.05) in line with the 'open-window-theory' but was unaffected by dehydration. Saliva flow rate decreased and saliva SIgA concentration increased post-exercise and during dehydration (P<0.05).Conclusion: Tear SIgA has utility as a non-invasive biomarker of mucosal immunity and common-cold risk.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Idrottsvetenskap (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Sport and Fitness Sciences (hsv//eng)
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- Av författaren/redakt...
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Hanstock, Helen, ...
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Walsh, Neil P
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Edwards, Jason P
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Fortes, Matthew ...
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Cosby, Sarah L
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Nugent, Aaron
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visa fler...
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Curran, Tanya
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Coyle, Peter V
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Ward, Mark D
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Aw Yong, Xin Hui
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visa färre...
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