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In-vitro digestion ...
In-vitro digestion of curcumin loaded chitosan-coated liposomes
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- Cuomo, Francesca (författare)
- Univ Molise, Campobasso, Italy,University of Molise
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- Cofelice, Martina (författare)
- Univ Molise, Campobasso, Italy,University of Molise
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- Venditti, Francesco (författare)
- Univ Molise, Campobasso, Italy,University of Molise
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- Ceglie, Andrea (författare)
- Univ Molise, Campobasso, Italy,University of Molise
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- Miguel, Maria (författare)
- Mid Sweden University,University of Coimbra
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- Lindman, Björn (författare)
- Mid Sweden University,Lund University,Lunds universitet,Mittuniversitetet,Avdelningen för kemiteknik,Lund Univ, Lund,Fysikalisk kemi,Enheten för fysikalisk och teoretisk kemi,Kemiska institutionen,Institutioner vid LTH,Lunds Tekniska Högskola,Physical Chemistry,Physical and theoretical chemistry,Department of Chemistry,Departments at LTH,Faculty of Engineering, LTH
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- Lopez, Francesco (författare)
- Univ Molise, Campobasso, Italy,University of Molise
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(creator_code:org_t)
- Elsevier BV, 2018
- 2018
- Engelska.
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Ingår i: Colloids and Surfaces B. - : Elsevier BV. - 0927-7765 .- 1873-4367. ; 168, s. 29-34
- Relaterad länk:
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http://dx.doi.org/10...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://lup.lub.lu.s...
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Abstract
Ämnesord
Stäng
- Liposomes are considered a major route for encapsulation of hydrophilic and hydrophobic molecules. Chitosan coated liposomes could represent an alternative way as a carrier for delivery of drugs in human body. In this study the preparation and applicability of chitosan-coated liposomes containing curcumin as well as curcumin loaded anionic liposomes were evaluated. The applicability of the carriers was tested by means of an in vitro digestion procedure allowing for measurement of the bioaccessibility of ingested curcumin. Values of diameter, polydispersity index and surface charge for curcumin loaded anionic liposomes obtained through dynamic light scattering and zeta-potential measurements were 129 nm, 0.095 and -49 mV, respectively. After chitosan-coating, diameter and polydispersity index remain unvaried while the surface charge gets positive. Slightly higher curcumin concentrations were found after the mouth and the stomach digestion phases when curcumin was loaded in anionic liposomes. On the contrary, after the intestinal phase, a higher percentage of curcumin was found when chitosan-coated liposomes were used as carrier, both in the raw digesta and in the bile salt micellar phase. It was shown that the presence of a positively charged surface allows a better absorption of curcumin in the small intestine phase, which increases the overall curcumin bioavailability. The mechanism behind these results can be understood from the composition of different environments generated by the digestive fluids that differently interact with anionic or cationic surfaces.
Ämnesord
- TEKNIK OCH TEKNOLOGIER -- Kemiteknik (hsv//swe)
- ENGINEERING AND TECHNOLOGY -- Chemical Engineering (hsv//eng)
- NATURVETENSKAP -- Kemi -- Fysikalisk kemi (hsv//swe)
- NATURAL SCIENCES -- Chemical Sciences -- Physical Chemistry (hsv//eng)
Nyckelord
- Chitosan
- Coated-liposomes
- Curcumin
- Digestion phase
- Bioavailability
- Bioavailability
- Chitosan
- Coated-liposomes
- Curcumin
- Digestion phase
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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