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Sökning: id:"swepub:oai:DiVA.org:oru-100776" > Heterogeneity of ph...

Heterogeneity of phosphatidylcholine metabolism in nonalcoholic fatty liver disease

Qadri, Sami (författare)
University of Helsinki and Helsinki University Hospital, Department of Medicine, Helsinki, Finland; Minerva Foundation Institute for Medical Research, Helsinki, Finland
Blom, Sami (författare)
Aiforia Technologies Oy, Helsinki, Finland
Pitkänen, Kari (författare)
Aiforia Technologies Oy, Helsinki, Finland
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Ahlholm, Noora (författare)
University of Helsinki and Helsinki University Hospital, Department of Medicine, Helsinki, Finland; Minerva Foundation Institute for Medical Research, Helsinki, Finland
Porthan, Kimmo (författare)
University of Helsinki and Helsinki University Hospital, Department of Medicine, Helsinki, Finland; Minerva Foundation Institute for Medical Research, Helsinki, Finland
Luukkonen, Panu K. (författare)
University of Helsinki and Helsinki University Hospital, Department of Medicine, Helsinki, Finland; Minerva Foundation Institute for Medical Research, Helsinki, Finland; Yale University, Department of Internal Medicine, New Haven, United States
Juuti, Anne (författare)
University of Helsinki and Helsinki University Hospital, Department of Gastrointestinal Surgery, Abdominal Center, Helsinki, Finland
Sammalkorpi, Henna (författare)
University of Helsinki and Helsinki University Hospital, Department of Gastrointestinal Surgery, Abdominal Center, Helsinki, Finland
Penttilä, Anne (författare)
University of Helsinki and Helsinki University Hospital, Department of Gastrointestinal Surgery, Abdominal Center, Helsinki, Finland
Arola, Johanna (författare)
University of Helsinki and Helsinki University Hospital, Department of Pathology, Helsinki, Finland
Oresic, Matej, 1967- (författare)
Örebro universitet,Institutionen för medicinska vetenskaper,University of Turku and Åbo Akademi University, Turku Bioscience Centre, Turku, Finland
Hyötyläinen, Tuulia, 1971- (författare)
Örebro universitet,Institutionen för naturvetenskap och teknik
Yki-Järvinen, Hannele (författare)
University of Helsinki and Helsinki University Hospital, Department of Medicine, Helsinki, Finland; Minerva Foundation Institute for Medical Research, Helsinki, Finland
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 (creator_code:org_t)
Elsevier, 2022
2022
Engelska.
Ingår i: Journal of Hepatology. - : Elsevier. - 0168-8278 .- 1600-0641. ; 77:Suppl. 1, s. S111-S111
Relaterad länk:
https://urn.kb.se/re...
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https://doi.org/10.1...
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  • Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)
Abstract Ämnesord
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  • Background and aims: In murine models of non-alcoholic fatty liver disease (NAFLD), liver damage associates with a deficiency of phosphatidylcholines (PCs), particularly polyunsaturated PCs (PUFA-PCs). We studied whether human PC metabolism is altered by NAFLD or by the protective genetic variant in HSD17B13 (rs72613567 T > TA).Method: In 143 obese patients with a liver biopsy and genotyping for HSD17B13 rs72613567, we analysed the hepatic lipidome (UPLC-MS). As the hepatic parenchymal fat fraction (HPFF) affects apparent concentrations of amphiphilic lipids, we normalised hepatic phospholipid concentrations to fat-free liver mass. To this end, we employed a state-of-the-art deep learning image analysis method (Aiforia Technologies) to accurately quantify HPFF in liver biopsies.Results: Total unadjusted hepatic PCs correlated negatively with HPFF (rs = −0.26, P < 0.01), but this association disappeared after normalising to fat-free liver mass (rs = 0.02, P = 0.81). With increasing HPFF, concentrations of especially saturated and monounsaturated PCs significantly increased, whereas concentrations of PUFA-PCs decreased. Accordingly, the hepatic triacylglycerol composition significantly correlated with that of hepatic PCs. In carriers of the protective variant in HSD17B13, as compared to non-carriers, the hepatic lipidome was enriched in especially PUFA-PCs.Conclusion: Patients with NAFLD have a deficiency of PUFA-PCs. The protective HSD17B13 rs72613567 variant opposes these changes, increasing intrahepatic PC concentrations.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Gastroenterologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Gastroenterology and Hepatology (hsv//eng)

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