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Multiple mediation ...
Multiple mediation effects on association between prenatal triclosan exposure and birth outcomes
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- Zhang, Jiming (författare)
- School of Public Health / MOE Key Laboratory of Public Health Safety / NHC Key Lab of Health Technology Assessment, Fudan University, Shanghai, China
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- Wang, Zheng (författare)
- School of Public Health / MOE Key Laboratory of Public Health Safety / NHC Key Lab of Health Technology Assessment, Fudan University, Shanghai, China
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- Dai, Yiming (författare)
- School of Public Health / MOE Key Laboratory of Public Health Safety / NHC Key Lab of Health Technology Assessment, Fudan University, Shanghai, China
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- Zhang, Lei (författare)
- School of Public Health / MOE Key Laboratory of Public Health Safety / NHC Key Lab of Health Technology Assessment, Fudan University, Shanghai, China
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- Guo, Jianqiu (författare)
- School of Public Health / MOE Key Laboratory of Public Health Safety / NHC Key Lab of Health Technology Assessment, Fudan University, Shanghai, China
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- Lv, Shenliang (författare)
- School of Public Health / MOE Key Laboratory of Public Health Safety / NHC Key Lab of Health Technology Assessment, Fudan University, Shanghai, China
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- Qi, Xiaojuan (författare)
- School of Public Health / MOE Key Laboratory of Public Health Safety / NHC Key Lab of Health Technology Assessment, Fudan University, Shanghai, China
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- Lu, Dasheng (författare)
- Shanghai Center for Disease Control and Prevention, Shanghai, China
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- Liang, Weijiu (författare)
- Changning Center for Disease Control and Prevention, No.39 Yunwushan Road, Shanghai, China
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- Cao, Yang, Associate Professor, 1972- (författare)
- Örebro universitet,Institutionen för medicinska vetenskaper,Region Örebro län,Unit of Integrative Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden,Clinical Epidemiology and Biostatistics
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- Wu, Chunhua (författare)
- School of Public Health / MOE Key Laboratory of Public Health Safety / NHC Key Lab of Health Technology Assessment, Fudan University, Shanghai, China
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- Chang, Xiuli (författare)
- School of Public Health / MOE Key Laboratory of Public Health Safety / NHC Key Lab of Health Technology Assessment, Fudan University, Shanghai, China
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- Zhou, Zhijun (författare)
- School of Public Health / MOE Key Laboratory of Public Health Safety / NHC Key Lab of Health Technology Assessment, Fudan University, Shanghai, China
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(creator_code:org_t)
- Elsevier, 2022
- 2022
- Engelska.
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Ingår i: Environmental Research. - : Elsevier. - 0013-9351 .- 1096-0953. ; 215:Part 1
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- BACKGROUND: Triclosan is a broad-spectrum antimicrobial, and was thought to affect intrauterine development, but the mechanism remains unclear.OBJECTIVE: To explore the association between prenatal triclosan exposure and birth outcomes.METHODS: Based on 726 mother-child pairs from the Sheyang Mini Birth Cohort Study (SMBCS), we used the available (published) data of triclosan in maternal urines, the hormones including thyroid-related hormones, gonadal hormones in cord blood, and adipokines, trimethylamine-N-oxide (TMAO) and its precursors in cord blood to explore possible health effects of triclosan on birth outcomes through assessing different hormones and parameters, using Bayesian mediation analysis.RESULTS: Maternal triclosan exposure was associated with ponderal index (β = 0.317) and head circumference (β = -0.172) in generalized linear models. In Bayesian mediation analysis of PI model, estradiol (β = 0.806) and trimethylamine (TMA, β = 0.164) showed positive mediation effects, while total thyroxine (TT4, β = -0.302), leptin (β = -2.023) and TMAO (β = -0.110) showed negative mediation effects. As for model of head circumference, positive mediation effects were observed in free thyroxine (FT4, β = 0.493), TMA (β = 0.178), and TMAO (β = 0.683), negative mediation effects were observed in TT4 (β = -0.231), testosterone (β = -0.331), estradiol (β = -1.153), leptin (β = -2.361), choline (β = -0.169), betaine (β = -0.104), acetyl-L-carnitine (β = -0.773).CONCLUSION: The results indicated triclosan can affect intrauterine growth by interfering thyroid-related hormones, gonadal hormones, adipokines, TMAO and its precursors.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Arbetsmedicin och miljömedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Occupational Health and Environmental Health (hsv//eng)
Nyckelord
- Bayesian mediation analysis
- Birth outcome
- Endocrine disruptor
- Mediation effect
- Triclosan
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Zhang, Jiming
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Wang, Zheng
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Dai, Yiming
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Zhang, Lei
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Guo, Jianqiu
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Lv, Shenliang
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Qi, Xiaojuan
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Lu, Dasheng
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Liang, Weijiu
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Cao, Yang, Assoc ...
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Wu, Chunhua
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Chang, Xiuli
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Zhou, Zhijun
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- MEDICIN OCH HÄLSOVETENSKAP
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Environmental Re ...
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Örebro universitet
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Karolinska Institutet