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Multi-Strain Probio...
Multi-Strain Probiotic Mixture Affects Brain Morphology and Resting State Brain Function in Healthy Subjects : An RCT
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- Rode, Julia, 1992- (författare)
- Örebro universitet,Institutionen för medicinska vetenskaper,Nutrition-Gut-Brain Interactions Research Centre
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- Edebol Carlman, Hanna M. T. (författare)
- Faculty of Medicine and Health, School of Medical Sciences, Örebro University, Örebro, Sweden,Nutrition-Gut-Brain Interactions Research Centre
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- König, Julia, 1983- (författare)
- Örebro universitet,Institutionen för medicinska vetenskaper,Nutrition-Gut-Brain Interactions Research Centre
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- Hutchinson, Ashley, 1984- (författare)
- Örebro universitet,Institutionen för medicinska vetenskaper,Nutrition-Gut-Brain Interactions Research Centre
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- Thunberg, Per, 1968- (författare)
- Örebro universitet,Institutionen för medicinska vetenskaper,Department of Radiology and Medical Physics
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- Persson, Jonas, 1971- (författare)
- Karolinska Institutet,Örebro universitet,Institutionen för juridik, psykologi och socialt arbete,Center for Lifespan Developmental Research (LEADER)
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- Brummer, Robert Jan, 1957- (författare)
- Örebro universitet,Institutionen för medicinska vetenskaper,Nutrition-Gut-Brain Interactions Research Centre
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(creator_code:org_t)
- 2022-09-19
- 2022
- Engelska.
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Ingår i: Cells. - : MDPI. - 2073-4409. ; 11:18
- Relaterad länk:
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https://doi.org/10.3...
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https://urn.kb.se/re...
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https://doi.org/10.3...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Probiotics can alter brain function via the gut-brain axis. We investigated the effect of a probiotic mixture containing Bifidobacterium longum, Lactobacillus helveticus and Lactiplantibacillus plantarum. In a randomized, placebo-controlled, double-blinded crossover design, 22 healthy subjects (6 m/16 f; 24.2 ± 3.4 years) underwent four-week intervention periods with probiotics and placebo, separated by a four-week washout period. Voxel-based morphometry indicated that the probiotic intervention affected the gray matter volume of a cluster covering the left supramarginal gyrus and superior parietal lobule (p < 0.0001), two regions that were also among those with an altered resting state functional connectivity. Probiotic intervention resulted in significant (FDR < 0.05) functional connectivity changes between regions within the default mode, salience, frontoparietal as well as the language network and several regions located outside these networks. Psychological symptoms trended towards improvement after probiotic intervention, i.e., the total score of the Hospital Anxiety and Depression Scale (p = 0.056) and its depression sub-score (p = 0.093), as well as sleep patterns (p = 0.058). The probiotic intervention evoked distinct changes in brain morphology and resting state brain function alongside slight improvements of psycho(bio)logical markers of the gut-brain axis. The combination of those parameters may provide new insights into the modes of action by which gut microbiota can affect gut-brain communication and hence brain function.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
Nyckelord
- CO2 inhalation challenge
- autonomic nervous system
- brain-derived neurotrophic factor (BDNF)
- cortisol awakening response
- gut microbiota
- mental health
- resting state functional connectivity
- serotonin
- sleep quality
- structural changes
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
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Cells
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Till lärosätets databas
- Av författaren/redakt...
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Rode, Julia, 199 ...
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Edebol Carlman, ...
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König, Julia, 19 ...
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Hutchinson, Ashl ...
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Thunberg, Per, 1 ...
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Persson, Jonas, ...
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Brummer, Robert ...
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- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Neurologi
- Artiklar i publikationen
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Cells
- Av lärosätet
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Örebro universitet
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Karolinska Institutet