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Placental Changes a...
Placental Changes and Neuropsychological Development in Children : A Systematic Review
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- Lodefalk, Maria, 1968- (författare)
- Örebro University,Örebro universitet,Institutionen för medicinska vetenskaper,Region Örebro län,Department of Pediatrics, Faculty of Medicine and Health, Örebro University, Örebro, Sweden; University Health Care Research Centre, Faculty of Medicine and Health, Örebro University, Örebro, Sweden
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- Chelslín, Felix, 1991- (författare)
- Örebro University,Örebro universitet,Institutionen för medicinska vetenskaper,Department of Pediatrics, Faculty of Medicine and Health, Örebro University, Örebro, Sweden
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- Patriksson Karlsson, Johanna (författare)
- Örebro University
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- Hansson, Stefan R. (författare)
- Lund University,Lunds universitet,Obstetrik och gynekologi, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Enheten för translationell obstetrisk forskning,Forskargrupper vid Lunds universitet,Obstetrics and Gynaecology (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine,Unit for translational obstetric research,Lund University Research Groups,Skåne University Hospital
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(creator_code:org_t)
- 2023-01-28
- 2023
- Engelska.
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Ingår i: Cells. - : MDPI. - 2073-4409. ; 12:3
- Relaterad länk:
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https://doi.org/10.3...
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http://dx.doi.org/10... (free)
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https://urn.kb.se/re...
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https://doi.org/10.3...
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https://lup.lub.lu.s...
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Abstract
Ämnesord
Stäng
- Placental dysfunction may increase the offspring's later-life disease risk. The objective of this systematic review was to describe associations between pathological placental changes and neuropsychological outcomes in children after the neonatal period. The inclusion criteria were human studies; original research; direct placental variables; neuropsychological outcomes; and analysis between their associations. The exclusion criterion was the offspring's age-0-28 days or >19 years. The MEDLINE and EMBASE databases were last searched in May 2022. We utilized the ROBINS-I for the risk of bias assessment and performed a narrative synthesis. In total, 3252 studies were identified, out of which 16 were included (i.e., a total of 15,862 participants). Half of the studies were performed on children with neonatal complications, and 75% of the studies reported an association between a placental change and an outcome; however, following the completion of the funnel plots, a risk of publication bias was indicated. The largest study described a small association between placental size and a risk of psychiatric symptoms in boys only. Inconsistency between the studies limited the evidence in this review. In general, no strong evidence was found for an association between pathological placental changes and childhood neuropsychological outcomes after the neonatal period. However, the association between placental size and mental health in boys indicates a placental sexual dimorphism, thereby suggesting an increased vulnerability for male fetuses.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reproduktionsmedicin och gynekologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Obstetrics, Gynaecology and Reproductive Medicine (hsv//eng)
Nyckelord
- Autism spectrum disorders
- childhood
- developmental origins of health and disease
- long-term outcome
- neuropsychological development
- pathological lesion
- placenta
- sexual dimorphism
- autism spectrum disorders
- childhood
- developmental origins of health and disease
- long-term outcome
- neuropsychological development
- pathological lesion
- placenta
- sexual dimorphism
Publikations- och innehållstyp
- ref (ämneskategori)
- for (ämneskategori)
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