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Outcome of transcra...
Outcome of transcranial magnetic intermittent theta-burst stimulation in the treatment of depression - A Swedish register-based study
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- Ekman, Carl Johan (författare)
- Karolinska Institutet
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- Popiolek, Katarzyna, 1981- (författare)
- Örebro universitet,Institutionen för medicinska vetenskaper,University Health Care Research Centre, Faculty of Medicine and Health, Örebro University, Örebro, Sweden,Örebro Univ, Univ Hlth Care Res Ctr, Fac Med & Hlth, Örebro, Sweden.
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- Bodén, Robert, 1973- (författare)
- Uppsala universitet,Psykiatri
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- Nordenskjöld, Axel, 1977- (författare)
- Örebro universitet,Institutionen för medicinska vetenskaper,University Health Care Research Centre, Faculty of Medicine and Health, Örebro University, Örebro, Sweden,Karolinska Inst, Ctr Psychiat Res, Dept Clin Neurosci, Solna, Region Stockhol, Sweden.;Stockholm Hlth Care Serv, Stockholm, Region Stockhol, Sweden.;Örebro Univ, Univ Hlth Care Res Ctr, Fac Med & Hlth, Örebro, Sweden.
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- Lundberg, Johan (författare)
- Karolinska Institutet
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(creator_code:org_t)
- Elsevier, 2023
- 2023
- Engelska.
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Ingår i: Journal of Affective Disorders. - : Elsevier. - 0165-0327 .- 1573-2517. ; 329, s. 50-54
- Relaterad länk:
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https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- BACKGROUND: Repetitive transcranial magnetic stimulation (rTMS) is an established treatment of depression. The more recently introduced intermittent Theta-burst stimulation (iTBS) has shown significant superiority over sham-stimulation and equal effect sizes to a 10 Hz protocol in one clinical trial. The aim of the current study was to investigate the effectiveness and tolerability of iTBS in a naturalistic, clinical setting. Further, we explored demographical and clinical predictors of response.METHODS: Data was collected from seventeen rTMS-sites in Sweden between January 2018 and May 2021, through the Swedish National Quality register for repetitive Transcranial Magnetic Stimulation (Q-rTMS). We included 542 iTBS-treated patients with unipolar or bipolar depression. Outcome was assessed with Clinical Global Impression Severity and Improvement scores in an intention to treat analysis.RESULTS: The response rate was 42.1 % and 16.1 % reached remission. The response rate was significantly larger in the oldest age group compared to the youngest (odds ratio 3.46, 95 % confidence interval 1.65-7.22). Less severe level of depression (Montgomery-Åsberg depression rating scale self-assessment < 36) at baseline predicted response and remission. Only <1 % were much or very much worse after treatment. Drop-out rate was 10.9 %. No serious adverse events were reported.LIMITATIONS: Retrospective analysis of register data. No comparison group.CONCLUSIONS: In a clinical setting, iTBS was shown to be safe and tolerable and the response rate was similar to that reported from clinical trials. Older age-group and less severe illness predicted response.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Psykiatri (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Psychiatry (hsv//eng)
Nyckelord
- Bipolar disorder
- Depression
- Theta-burst stimulation
- Transcranial magnetic stimulation
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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