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Do Poor Diet and Li...
Do Poor Diet and Lifestyle Behaviors Modify the Genetic Susceptibility to Impulsivity in the General Population?
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- Xie, Tian (författare)
- Interdisciplinary Center Psychopathology and Emotion Regulation (ICPE), Department of Psychiatry, University Medical Center Groningen, University of Groningen, Hanzeplein 1, 9700 RB Groningen, The Netherlands; Department of Epidemiology, University Medical Center Groningen, University of Groningen, Hanzeplein 1, 9700 RB Groningen, The Netherlands
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- Schweren, Lizanne J. S. (författare)
- Interdisciplinary Center Psychopathology and Emotion Regulation (ICPE), Department of Psychiatry, University Medical Center Groningen, University of Groningen, Hanzeplein 1, 9700 RB Groningen, The Netherlands
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- Larsson, Henrik, 1975- (författare)
- Örebro universitet,Institutionen för medicinska vetenskaper,Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, 17165 Stockholm, Sweden
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- Li, Lin (författare)
- Karolinska Institutet
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- Du Rietz, Ebba (författare)
- Karolinska Institutet
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- Haavik, Jan (författare)
- Department of Biomedicine, University of Bergen, 5020 Bergen, Norway; Bergen Center for Brain Plasticity, Division of Psychiatry, Haukeland University Hospital, 5012 Bergen, Norway
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- Grimstvedt Kvalvik, Liv (författare)
- Department of Global Public Health and Primary Care, University of Bergen, 5020 Bergen, Norway
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- Solberg, Berit Skretting (författare)
- Department of Biomedicine, University of Bergen, 5020 Bergen, Norway; Child- and Adolescent Psychiatric Outpatient Unit, Hospital Betanien, 5143 Bergen, Norway
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- Klungsøyr, Kari (författare)
- Department of Global Public Health and Primary Care, University of Bergen, 5020 Bergen, Norway; Division of Mental and Physical Health, Norwegian Institute of Public Health, 5015 Bergen, Norway
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- Snieder, Harold (författare)
- Department of Epidemiology, University Medical Center Groningen, University of Groningen, Hanzeplein 1, 9700 RB Groningen, The Netherlands
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- Hartman, Catharina A. (författare)
- Interdisciplinary Center Psychopathology and Emotion Regulation (ICPE), Department of Psychiatry, University Medical Center Groningen, University of Groningen, Hanzeplein 1, 9700 RB Groningen, The Netherlands
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Lifelines Cohort Study, - (bidragsgivare)
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(creator_code:org_t)
- 2023-03-27
- 2023
- Engelska.
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Ingår i: Nutrients. - : MDPI. - 2072-6643. ; 15:7
- Relaterad länk:
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https://doi.org/10.3...
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https://urn.kb.se/re...
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https://doi.org/10.3...
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http://kipublication...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- The present study investigated whether an unhealthy diet and other lifestyle behaviors may modify the genetic susceptibility to impulsivity. A total of 33,047 participants (mean age = 42.1 years, 59.8% females) from the Dutch Lifelines cohort were included. Each diet index and other lifestyle behaviors were tested for their interactions on the effect on the attention-deficit/hyperactivity disorder (ADHD) polygenic risk score (PRS) on impulsivity using a linear regression model with adjustment for covariates. The ADHD PRS was significantly associated with impulsivity (B = 0.03 (95% CI: 0.02, 0.04); p = 2.61 × 10-9). A poorer diet, a higher intake of energy, and a higher intake of fat were all associated with higher impulsivity, and a high intake of energy amplified the effect of ADHD PRS on impulsivity (e.g., for the interaction term of ADHD PRS and highest tertile on intake of energy, B = 0.038 (95% CI: 0.014, 0.062); p = 0.002. The other lifestyle factors, namely short and long sleep duration, current and past smoking, higher alcohol intake, and more time spent on moderate-to-vigorous physical activity were associated with higher impulsivity, but no interaction effect was observed. In conclusion, we found that a high intake of energy exacerbated the genetic susceptibility to impulsivity. Our study helps to improve our understanding of the role of diet and genetic factors on impulsivity.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Näringslära (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Nutrition and Dietetics (hsv//eng)
Nyckelord
- Diet-gene interaction
- dietary habits
- genetic susceptibility
- impulsivity
- lifestyle behaviors
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
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Xie, Tian
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Schweren, Lizann ...
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Larsson, Henrik, ...
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Li, Lin
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Du Rietz, Ebba
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Haavik, Jan
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visa fler...
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Grimstvedt Kvalv ...
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Solberg, Berit S ...
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Klungsøyr, Kari
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Snieder, Harold
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Hartman, Cathari ...
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Lifelines Cohort ...
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visa färre...
- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Hälsovetenskap
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och Näringslära
- Artiklar i publikationen
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Nutrients
- Av lärosätet
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Örebro universitet
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Karolinska Institutet