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Inter-host Transmission of Carbapenemase-Producing Escherichia coli among Humans and Backyard Animals

Li, Jiyun (författare)
Beijing Advanced Innovation Center for Food Nutrition and Human Health, College of Veterinary Medicine, China Agricultural University, Beijing, China College of Veterinary Medicine, Hunan Agricultural University, Changsha, Hunan, China,China Agr Univ, Peoples R China; Hunan Agr Univ, Peoples R China
Bi, Zhenwang (författare)
Shandong Academy of Clinical Medicine, Shandong Provincial Hospital, Jinan, Shandong, China,Shandong Acad Clin Med, Peoples R China
Ma, Shizhen (författare)
Beijing Advanced Innovation Center for Food Nutrition and Human Health, College of Veterinary Medicine, China Agricultural University, Beijing, China,China Agr Univ, Peoples R China
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Chen, Baoli (författare)
Shandong Provincial Key Laboratory of Infectious Disease Control and Prevention, Shandong Center for Disease Control and Prevention, Jinan, Shandong, China,Shandong Ctr Dis Control and Prevent, Peoples R China
Cai, Chang (författare)
China Australia Joint Laboratory for Animal Health Big Data Analytics, College of Animal Science and Technology, Zhejiang Agricultural and Forestry University, Hangzhou, China Research and Innovation Office, Murdoch University, Murdoch, Australia,Zhejiang Agr and Forestry Univ, Peoples R China; Murdoch Univ, Australia
He, Junjia (författare)
Beijing Advanced Innovation Center for Food Nutrition and Human Health, College of Veterinary Medicine, China Agricultural University, Beijing, China,China Agr Univ, Peoples R China
Schwarz, Stefan (författare)
Beijing Advanced Innovation Center for Food Nutrition and Human Health, College of Veterinary Medicine, China Agricultural University, Beijing, China; Institute of Microbiology and Epizootics, Centre for Infection Medicine, Department of Veterinary Medicine, Freie Universität Berlin, Berlin, Germany,China Agr Univ, Peoples R China; Free Univ Berlin, Germany
Sun, Chengtao (författare)
Beijing Advanced Innovation Center for Food Nutrition and Human Health, College of Veterinary Medicine, China Agricultural University, Beijing, China,China Agr Univ, Peoples R China
Zhou, Yuqing (författare)
Beijing Advanced Innovation Center for Food Nutrition and Human Health, College of Veterinary Medicine, China Agricultural University, Beijing, China,China Agr Univ, Peoples R China
Yin, Jia (författare)
School of Health Care Management, Shandong University, Jinan, China; NHC Key Laboratory of Health Economics and Policy Research (Shandong University), Jinan, China,Shandong Univ, Peoples R China; Shandong Univ, Peoples R China
Hulth, Anette (författare)
Karolinska Institutet,Karolinska Inst, Sweden; Publ Hlth Agcy Sweden, Sweden
Wang, Yongqiang (författare)
Beijing Advanced Innovation Center for Food Nutrition and Human Health, College of Veterinary Medicine, China Agricultural University, Beijing, China,China Agr Univ, Peoples R China
Shen, Zhangqi (författare)
Beijing Advanced Innovation Center for Food Nutrition and Human Health, College of Veterinary Medicine, China Agricultural University, Beijing, China,China Agr Univ, Peoples R China
Wang, Shaolin (författare)
Beijing Advanced Innovation Center for Food Nutrition and Human Health, College of Veterinary Medicine, China Agricultural University, Beijing, China,China Agr Univ, Peoples R China
Wu, Congming (författare)
Beijing Advanced Innovation Center for Food Nutrition and Human Health, College of Veterinary Medicine, China Agricultural University, Beijing, China,China Agr Univ, Peoples R China
Nilsson, Lennart E (författare)
Linköpings universitet,Avdelningen för mikrobiologi, infektion och inflammation,Medicinska fakulteten
Walsh, Timothy R (författare)
Beijing Advanced Innovation Center for Food Nutrition and Human Health, College of Veterinary Medicine, China Agricultural University, Beijing, China; Department of Medical Microbiology and Infectious Disease, Division of Infection and Immunity, Cardiff University, Cardiff, UK,China Agr Univ, Peoples R China; Cardiff Univ, Wales
Börjesson, Stefan, 1979- (författare)
Linköpings universitet,Avdelningen för mikrobiologi, infektion och inflammation,Medicinska fakulteten,Natl Vet Inst SVA, Sweden
Shen, Jianzhong (författare)
Beijing Advanced Innovation Center for Food Nutrition and Human Health, College of Veterinary Medicine, China Agricultural University, Beijing, China; Beijing Laboratory of Food Quality and Safety, College of Veterinary Medicine, China Agricultural University, Beijing, China,China Agr Univ, Peoples R China
Sun, Qiang (författare)
School of Health Care Management, Shandong University, Jinan, China; NHC Key Laboratory of Health Economics and Policy Research (Shandong University), Jinan, China,Shandong Univ, Peoples R China
Wang, Yang (författare)
Beijing Advanced Innovation Center for Food Nutrition and Human Health, College of Veterinary Medicine, China Agricultural University, Beijing 100194, China,China Agr Univ, Peoples R China
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 (creator_code:org_t)
U.S. Department of Health and Human Services, National Institute of Environmental Health Sciences, 2019
2019
Engelska.
Ingår i: Journal of Environmental Health Perspectives. - : U.S. Department of Health and Human Services, National Institute of Environmental Health Sciences. - 0091-6765 .- 1552-9924. ; 127:10
Relaterad länk:
https://doi.org/10.1...
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https://urn.kb.se/re...
https://doi.org/10.1...
http://kipublication...
https://urn.kb.se/re...
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  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
Stäng  
  • BACKGROUND: The rapidly increasing dissemination of carbapenem-resistant Enterobacteriaceae (CRE) in both humans and animals poses a global threat to public health. However, the transmission of CRE between humans and animals has not yet been well studied.OBJECTIVES: We investigated the prevalence, risk factors, and drivers of CRE transmission between humans and their backyard animals in rural China.METHODS: We conducted a comprehensive sampling strategy in 12 villages in Shandong, China. Using the household [residents and their backyard animals (farm and companion animals)] as a single surveillance unit, we assessed the prevalence of CRE at the household level and examined the factors associated with CRE carriage through a detailed questionnaire. Genetic relationships among human- and animal-derived CRE were assessed using whole-genome sequencing-based molecular methods.RESULTS: A total of 88 New Delhi metallo beta lactamasesmetallo-β-lactamases–type carbapenem-resistant Escherichia coli (NDM-EC), including 17 from humans, 44 from pigs, 12 from chickens, 1 from cattle, and 2 from dogs, were isolated from 65 of the 746 households examined. The remaining 12 NDM-EC were from flies in the immediate backyard environment. The NDM-EC colonization in households was significantly associated with a) the number of species of backyard animals raised/kept in the same household, and b) the use of human and/or animal feces as fertilizer. Discriminant analysis of principal components (DAPC) revealed that a large proportion of the core genomes of the NDM-EC belonged to strains from hosts other than their own, and several human isolates shared closely related core single-nucleotide polymorphisms and bla sub NDMblaNDM genetic contexts with isolates from backyard animals.CONCLUSIONS: To our knowledge, we are the first to report evidence of direct transmission of NDM-EC between humans and animals. Given the rise of NDM-EC in community and hospital infections, combating NDM-EC transmission in backyard farm systems is needed. https://doi.org/10.1289/EHP5251.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Mikrobiologi inom det medicinska området (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Microbiology in the medical area (hsv//eng)
NATURVETENSKAP  -- Biologi -- Mikrobiologi (hsv//swe)
NATURAL SCIENCES  -- Biological Sciences -- Microbiology (hsv//eng)
NATURVETENSKAP  -- Biologi -- Annan biologi (hsv//swe)
NATURAL SCIENCES  -- Biological Sciences -- Other Biological Topics (hsv//eng)

Nyckelord

Animals; Animals
Domestic; Bacterial Proteins; beta-Lactamases; Carbapenem-Resistant Enterobacteriaceae; Cattle; China; Dogs; Drug Resistance
Multiple
Bacterial; Escherichia coli; Humans; Swine; Zoonoses

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