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MDS-Comorbidity Ind...
MDS-Comorbidity Index using register data has prognostic impact in Swedish MDS patients
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- Larfors, Gunnar (författare)
- Uppsala universitet,Hematologi
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- Moreno Berggren, Daniel (författare)
- Uppsala universitet,Hematologi
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- Garelius, Hege (författare)
- Section of Haematology and Coagulation, Department of Specialist Medicine, Sahlgrenska University Hospital, Gothenburg, Sweden,Sahlgrens Univ Hosp, Dept Specialist Med, Sect Haematol & Coagulat, Gothenburg, Sweden.
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- Nilsson, Lars (författare)
- Department of Haematology, Oncology and Radiation Physics, Skåne University Hospital, Lund, Sweden,Skane Univ Hosp, Dept Haematol Oncol & Radiat Phys, Lund, Sweden.
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- Rasmussen, Bengt, 1970- (författare)
- Örebro universitet,Institutionen för medicinska vetenskaper,Department of Medicine, Faculty of Medicine and Health, Örebro University, Örebro, Sweden,Örebro Univ, Fac Med & Hlth, Dept Med, Örebro, Sweden.
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- Hellström-Lindberg, Eva (författare)
- Karolinska Institutet,Karolinska Univ Hosp, Karolinska Inst, Dept Med Huddinge, Ctr Haematol & Regenerat Med, Stockholm, Sweden.
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- Ejerblad, Elisabeth (författare)
- Uppsala universitet,Hematologi
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(creator_code:org_t)
- Elsevier, 2023
- 2023
- Engelska.
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Ingår i: Leukemia Research. - : Elsevier. - 0145-2126 .- 1873-5835. ; 134
- Relaterad länk:
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https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- Comorbidities influence the mortality in patients with myelodysplastic syndromes, and a growing body of evidence suggest that comorbidity history should be used in addition to established prognostic indices. A comorbidity index specific for MDS, the MDS-CI, was introduced a decade ago. In this study we aim to construct an MDS-CI version based on diagnoses from register data only, to expand its use beyond the clinical setting to retrospective and register based studies. We further test this version on a Swedish population-based MDS cohort of 2947 patients, and compare its prognostic accuracy to that of Charlson Comorbidity Index. Our register based MDS-CI divided patients into three risk groups of similar proportions as have been published for the original MDS-CI. Compared to low risk patients, intermediate and high risk patients had 50 % and 70 % higher mortality, respectively. The prognostic value of MDS-CI was equal to that of Charlson comorbidity index. Adding MDS-CI to the established prognostic factors IPSS-R and age increased the prognostic accuracy. In summary, we demonstrate that MDS-CI can be adequately estimated from diagnoses recorded in registers only, and that it is a useful tool in any future study on myelodysplastic syndromes with a need to adjust for comorbidities.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Hematologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Hematology (hsv//eng)
Nyckelord
- Cohort studies
- Comorbidity
- Epidemiology
- Myelodysplastic syndromes
- Prognosis
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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