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Sökning: id:"swepub:oai:DiVA.org:oru-110591" > Profiling the dysre...

Profiling the dysregulated immune response in sepsis : overcoming challenges to achieve the goal of precision medicine

Cajander, Sara, 1980- (författare)
Örebro universitet,Institutionen för medicinska vetenskaper,Department of Infectious Diseases, Faculty of Medicine and Health, Örebro University, Örebro, Sweden
Kox, Matthijs (författare)
Department of Intensive Care Medicine and Radboud Center for Infectious Diseases, Radboud University Medical Center, Nijmegen, Netherlands
Scicluna, Brendon P. (författare)
Department of Applied Biomedical Science, Faculty of Health Sciences, Mater Dei hospital, University of Malta, Msida, Malta; Centre for Molecular Medicine and Biobanking, University of Malta, Msida, Malta
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Weigand, Markus A. (författare)
Department of Anesthesiology, Heidelberg University Hospital, Heidelberg, Germany
Mora, Raquel Almansa (författare)
Department of Cell Biology, Genetics, Histology and Pharmacology, University of Valladolid, Valladolid, Spain
Flohé, Stefanie B. (författare)
Department of Trauma, Hand, and Reconstructive Surgery, University Hospital Essen, University of Duisburg-Essen, Essen, Germany
Martin-Loeches, Ignacio (författare)
St James's Hospital, Dublin, Ireland; Hospital Clinic, Institut D'Investigacions Biomediques August Pi i Sunyer, Universidad de Barcelona, Barcelona, Spain
Lachmann, Gunnar (författare)
Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Department of Anesthesiology and Operative Intensive Care Medicine, Berlin, Germany
Girardis, Massimo (författare)
Department of Intensive Care and Anesthesiology, University Hospital of Modena, Modena, Italy
Garcia-Salido, Alberto (författare)
Hospital Infantil Universitario Niño Jesús, Pediatric Critical Care Unit, Madrid, Spain
Brunkhorst, Frank M. (författare)
Department of Anesthesiology and Intensive Care Medicine, Jena University Hospital, Jena, Germany
Bauer, Michael (författare)
Department of Anesthesiology and Intensive Care Medicine, Jena University Hospital, Jena, Germany; Integrated Research and Treatment Center, Center for Sepsis Control and Care, Jena University Hospital, Jena, Germany
Torres, Antoni (författare)
Pulmonology Department. Hospital Clinic of Barcelona, University of Barcelona, Ciberes, IDIBAPS, ICREA, Barcelona, Spain
Cossarizza, Andrea (författare)
Department of Medical and Surgical Sciences for Children and Adults, University of Modena and Reggio Emilia, Modena, Italy
Monneret, Guillaume (författare)
Immunology Laboratory, Hôpital E Herriot - Hospices Civils de Lyon, Lyon, France; Université Claude Bernard Lyon-1, Hôpital E Herriot, Lyon, France
Cavaillon, Jean-Marc (författare)
Institut Pasteur, Paris, France
Shankar-Hari, Manu (författare)
Centre for Inflammation Research, Institute of Regeneration and Repair, The University of Edinburgh, Edinburgh, UK
Giamarellos-Bourboulis, Evangelos J. (författare)
4th Department of Internal Medicine, National and Kapodistrian University of Athens, Medical School, Athens, Greece
Winkler, Martin Sebastian (författare)
Department of Anesthesiology and Intensive Care, Universitätsmedizin Göttingen, Göttingen, Germany
Skirecki, Tomasz (författare)
Department of Translational Immunology and Experimental Intensive Care, Centre of Postgraduate Medical Education, Warsaw, Poland
Osuchowski, Marcin (författare)
Ludwig Boltzmann Institute for Traumatology, The Research Center in Cooperation with AUVA, Vienna, Austria
Rubio, Ignacio (författare)
Department of Anesthesiology and Intensive Care Medicine, Jena University Hospital, Jena, Germany; Integrated Research and Treatment Center, Center for Sepsis Control and Care, Jena University Hospital, Jena, Germany
Bermejo-Martin, Jesus F. (författare)
Instituto de Investigación Biomédica de Salamanca, Salamanca, Spain; School of Medicine, Universidad de Salamanca, Salamanca, Spain; Centro de Investigación Biomédica en Red en Enfermedades Respiratorias, Instituto de Salud Carlos III, Madrid, Spain
Schefold, Joerg C. (författare)
Department of Intensive Care Medicine, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland
Venet, Fabienne (författare)
Immunology Laboratory, Hôpital E Herriot - Hospices Civils de Lyon, Lyon, France; Centre International de Recherche en Infectiologie, Inserm U1111, CNRS, UMR5308, Ecole Normale Supeérieure de Lyon, Universiteé Claude Bernard-Lyon 1, Lyon, France
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 (creator_code:org_t)
Elsevier, 2024
2024
Engelska.
Ingår i: The Lancet Respiratory Medicine. - : Elsevier. - 2213-2600 .- 2213-2619. ; 12:4, s. 305-322
  • Forskningsöversikt (refereegranskat)
Abstract Ämnesord
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  • Sepsis is characterised by a dysregulated host immune response to infection. Despite recognition of its significance, immune status monitoring is not implemented in clinical practice due in part to the current absence of direct therapeutic implications. Technological advances in immunological profiling could enhance our understanding of immune dysregulation and facilitate integration into clinical practice. In this Review, we provide an overview of the current state of immune profiling in sepsis, including its use, current challenges, and opportunities for progress. We highlight the important role of immunological biomarkers in facilitating predictive enrichment in current and future treatment scenarios. We propose that multiple immune and non-immune-related parameters, including clinical and microbiological data, be integrated into diagnostic and predictive combitypes, with the aid of machine learning and artificial intelligence techniques. These combitypes could form the basis of workable algorithms to guide clinical decisions that make precision medicine in sepsis a reality and improve patient outcomes.

Ämnesord

NATURVETENSKAP  -- Biologi -- Immunologi (hsv//swe)
NATURAL SCIENCES  -- Biological Sciences -- Immunology (hsv//eng)

Nyckelord

Infektionssjukdomar
Infectious Diseases
Anestesiologi
Anaesthesiology

Publikations- och innehållstyp

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