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Long-term cognitive impairment without diffuse axonal injury following repetitive mild traumatic brain injury in rats

Tadepalli, Sai Ambika (författare)
Department of Experimental Zoology and Neurobiology, Faculty of Sciences, University of Pécs, Pécs, Hungary; Translational Neuroscience Research Group, Szentágothai Research Centre, University of Pécs, Pécs, Hungary; Center for Neuroscience, Szentágothai Research Centre, University of Pécs, Pécs, Hungary
Bali, Zsolt Kristóf (författare)
Translational Neuroscience Research Group, Szentágothai Research Centre, University of Pécs, Pécs, Hungary; Center for Neuroscience, Szentágothai Research Centre, University of Pécs, Pécs, Hungary; Grastyán Translational Research Centre, University of Pécs, Pécs, Hungary
Bruszt, Nóra (författare)
Translational Neuroscience Research Group, Szentágothai Research Centre, University of Pécs, Pécs, Hungary; Center for Neuroscience, Szentágothai Research Centre, University of Pécs, Pécs, Hungary; Institute of Physiology, Medical School, University of Pécs, Pécs Hungary
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Nagy, Lili Veronika (författare)
Department of Experimental Zoology and Neurobiology, Faculty of Sciences, University of Pécs, Pécs, Hungary; Translational Neuroscience Research Group, Szentágothai Research Centre, University of Pécs, Pécs, Hungary; Center for Neuroscience, Szentágothai Research Centre, University of Pécs, Pécs, Hungary
Amrein, Krisztina (författare)
Center for Neuroscience, Szentágothai Research Centre, University of Pécs, Pécs, Hungary; Department of Neurosurgery, Medical School, University of Pécs, Pécs, Hungary; Neurotrauma Research Group, Szentágothai Research Centre, University of Pécs, Pécs, Hungary
Fazekas, Bálint (författare)
Center for Neuroscience, Szentágothai Research Centre, University of Pécs, Pécs, Hungary; Department of Neurosurgery, Medical School, University of Pécs, Pécs, Hungary; Neurotrauma Research Group, Szentágothai Research Centre, University of Pécs, Pécs, Hungary
Büki, Andras, 1966- (författare)
Center for Neuroscience, Szentágothai Research Centre, University of Pécs, Pécs, Hungary; Department of Neurosurgery, Medical School, University of Pécs, Pécs, Hungary; Neurotrauma Research Group, Szentágothai Research Centre, University of Pécs, Pécs, Hungary
Czeiter, Endre (författare)
Center for Neuroscience, Szentágothai Research Centre, University of Pécs, Pécs, Hungary; Department of Neurosurgery, Medical School, University of Pécs, Pécs, Hungary; Neurotrauma Research Group, Szentágothai Research Centre, University of Pécs, Pécs, Hungary; MTA-PTE Clinical Neuroscience MR Research Group, Pécs, Hungary
Hernádi, István (författare)
Department of Experimental Zoology and Neurobiology, Faculty of Sciences, University of Pécs, Pécs, Hungary; Translational Neuroscience Research Group, Szentágothai Research Centre, University of Pécs, Pécs, Hungary; Center for Neuroscience, Szentágothai Research Centre, University of Pécs, Pécs, Hungary; Grastyán Translational Research Centre, University of Pécs, Pécs, Hungary; Institute of Physiology, Medical School, University of Pécs, Pécs Hungary
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 (creator_code:org_t)
Elsevier, 2020
2020
Engelska.
Ingår i: Behavioural Brain Research. - : Elsevier. - 0166-4328 .- 1872-7549. ; 378
Relaterad länk:
https://doi.org/10.1...
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https://doi.org/10.1...
https://urn.kb.se/re...
https://doi.org/10.1...
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  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
Stäng  
  • Repetitive mild traumatic brain injuries (TBI) impair cognitive abilities and increase risk of neurodegenerative disorders in humans. We developed two repetitive mild TBI models in rats with different time intervals between successive weight-drop injuries. Rats were subjected to repetitive Sham (no injury), single mild (mTBI), repetitive mild (rmTBI - 5 hits, 24 h apart), rapid repetitive mild (rapTBI - 5 hits, 5 min apart) or a single severe (sTBI) TBI. Cognitive performance was assessed 2 and 8 weeks after TBI in the novel object recognition test (NOR), and 6-7 weeks after TBI in the water maze (MWM). Acute immunohistochemical markers were evaluated 24 h after TBI, and blood biomarkers were measured with ELISA 8 weeks after TBI. In the NOR, both rmTBI and rapTBI showed poor performance at 2 weeks post-injury. At 8 weeks post-injury, the rmTBI group still performed worse than the Sham and mTBI groups, while the rapTBI group recovered. In the MWM, the rapTBI group performed worse than the Sham and mTBI groups. Acute APP and RMO-14 immunohistochemistry showed axonal injury at the pontomedullary junction in the sTBI, but not in other groups. ELISA showed increased serum GFAP levels 8 weeks after sTBI, while no differences were found between the injury groups in the levels of phosphorylated-tau and S100β. Results suggest that the rmTBI protocol is the most suitable model for testing cognitive impairment after mild repetitive head injuries and that the prolonged cognitive impairment after repetitive mild TBI originates from different structural and molecular mechanisms compared to similar impairments after single sTBI. 

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Neurologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Neurology (hsv//eng)

Nyckelord

Amyloid precursor protein
chronic traumatic encephalopathy
glial fibrillary acidic protein
memory
novel object recognition
water maze

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