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Granulocyte, monocy...
Granulocyte, monocyte/macrophage apheresis for inflammatory bowel disease : the first 100 patients treated in Scandinavia
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- Ljung, Tryggve (författare)
- Karolinska University Hospital
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Thomsen, Ole Østergaard (författare)
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- Vatn, Morten (författare)
- University of Oslo
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- Karlén, Per (författare)
- Karolinska Institutet,Soder Hospital, Stockholm
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- Karlsen, Lars Norman (författare)
- Rogaland Hospital, Stavanger
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- Tysk, Curt (författare)
- Örebro universitet,Hälsoakademin,Örebro University Hospital
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- Nilsson, Stefan U. (författare)
- Kristianstad Hospital
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- Kilander, Anders (författare)
- Sahlgrenska University Hospital
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- Gillberg, Rolf (författare)
- Sahlgrenska University Hospital
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- Grip, Olof (författare)
- Lund University,Lunds universitet,Enheten för kroniska inflammatoriska och degenerativa sjukdomar,Forskargrupper vid Lunds universitet,Chronic Inflammatory and Degenerative Diseases Research Unit,Lund University Research Groups,Malmö University Hospital
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- Lindgren, Stefan (författare)
- Lund University,Lunds universitet,Enheten för kroniska inflammatoriska och degenerativa sjukdomar,Forskargrupper vid Lunds universitet,Chronic Inflammatory and Degenerative Diseases Research Unit,Lund University Research Groups,Malmö University Hospital
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- Befrits, Ragnar (författare)
- Karolinska Institutet,Karolinska University Hospital
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- Löfberg, Robert (författare)
- Karolinska Institutet,Karolinska University Hospital
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- Thomsen, OO (författare)
- University of Copenhagen
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(creator_code:org_t)
- 2009-07-08
- 2007
- Engelska.
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Ingår i: Scandinavian Journal of Gastroenterology. - Oslo : Taylor & Francis. - 0036-5521 .- 1502-7708. ; 42:2, s. 221-227
- Relaterad länk:
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http://dx.doi.org/10...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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https://lup.lub.lu.s...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- OBJECTIVE: Selective leukocyte apheresis is a new type of non-pharmacological treatment for patients with active ulcerative colitis and Crohn's disease. Preliminary data have indicated that this type of therapy is safe and efficacious, and large sham-controlled studies are currently in progress. In Scandinavia, a substantial number of patients with chronic inflammatory bowel disease have already received leukocyte apheresis on a compassionate use basis and the aim of this study was to report the clinical outcome and adverse events in the first patients treated. MATERIAL AND METHODS: Clinical details of the first consecutive 100 patients with inflammatory bowel disease treated with granulocyte, monocyte/macrophage (Adacolumn) apheresis in Scandinavia were prospectively registered. Median length of follow-up was 17 months, (range 5-30). RESULTS: The study population comprised 52 patients with ulcerative colitis, 44 patients with Crohn's disease and 4 patients with indeterminate colitis. In 97 patients the indication for Adacolumn treatment was steroid-refractory or steroid-dependent disease. Clinical remission was attained in 48% of the patients with ulcerative colitis, and an additional 27% had a clinical response to the apheresis treatment. The corresponding figures for patients with Crohn's disease were 41% and 23%, respectively. Complete steroid withdrawal was achieved in 27 out of the 50 patients taking corticosteroids at baseline. Adverse events were reported in 15 patients and headache was most frequently reported (n=7). CONCLUSIONS: Granulocyte, monocyte/macrophage apheresis treatment seems to be a valuable adjuvant therapy in selected patients with refractory inflammatory bowel disease. The risk for toxicity or severe adverse events appears to be low.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Gastroenterologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Gastroenterology and Hepatology (hsv//eng)
Nyckelord
- MEDICINE
- MEDICIN
- Gastroenterology
- Gastroenterologi
- Medicine
- medicin
- inflammatory bowel disease
- ulcerative colitis
- leukocytes
- Crohn's disease
- apheresis
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Ljung, Tryggve
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Thomsen, Ole Øst ...
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Vatn, Morten
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Karlén, Per
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Karlsen, Lars No ...
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Tysk, Curt
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visa fler...
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Nilsson, Stefan ...
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Kilander, Anders
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Gillberg, Rolf
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Grip, Olof
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Lindgren, Stefan
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Befrits, Ragnar
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Löfberg, Robert
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Thomsen, OO
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- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Gastroenterologi
- Artiklar i publikationen
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Scandinavian Jou ...
- Av lärosätet
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Örebro universitet
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Karolinska Institutet
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Lunds universitet
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Linköpings universitet