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Risk of prostate ca...
Risk of prostate cancer in a population-based cohort of men with coeliac disease
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- Ludvigsson, Jonas F., 1969- (författare)
- Karolinska Institutet
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- Fall, Katja, 1971- (författare)
- Örebro universitet,Institutionen för hälsovetenskap och medicin,Department of Epidemiology, Harvard School of Public Health, Boston, US,Clinical Epidemiology and Biostatistics
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- Montgomery, Scott M., 1961- (författare)
- Karolinska Institutet,Örebro universitet,Institutionen för hälsovetenskap och medicin,Clinical Epidemiology Unit, Department of Medicine, Karolinska Institutet, Stockholm, Sweden; Department of Primary Care and Public Health, Charing Cross Hospital, Imperial College, London, UK,Clinical Epidemiology and Biostatistics
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(creator_code:org_t)
- 2011-12-01
- 2012
- Engelska.
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Ingår i: British Journal of Cancer. - London, United Kingdom : Nature Publishing Group. - 0007-0920 .- 1532-1827. ; 106:1, s. 217-221
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https://www.nature.c...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Background: Prostate cancer (PC) is a leading cause of fatal cancer in men in developed countries. Coeliac disease (CD) has previously been linked to a raised cancer risk, and changes in some exposures following a CD diagnosis might hypothetically raise PC risk.Methods: We identified 10 995 patients with CD who had undergone a small intestinal biopsy in 1969-2007. Statistics Sweden then identified 54 233 age-matched male reference individuals from the general population. PC data were obtained from the Swedish Cancer Register. Hazard ratios (HRs) for PC were estimated using Cox regression analysis.Results: During follow-up, 185 individuals with CD (expected = 200) had an incident diagnosis of PC. This corresponds to a HR of 0.92 (0.79-1.08) (with 95% confidence interval) and an absolute risk reduction of 15/100 000 person-years among those with CD. An increased risk was not observed even when identification of PC began 5 years after biopsy.Conclusion: Our conclusion is that a CD diagnosis does not represent an increased risk for PC.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Gastroenterologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Gastroenterology and Hepatology (hsv//eng)
Nyckelord
- Coeliac disease
- cohort study
- inflammation
- prostate
- Medicine
- Medicin
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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