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Comparison of host ...
Comparison of host response mechanisms evoked by extended spectrum beta lactamase (ESBL)- and non-ESBL-producing uropathogenic E. coli
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- Demirel, Isak, 1987- (författare)
- Örebro universitet,Institutionen för hälsovetenskap och medicin
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- Kinnunen, Annica, 1987- (författare)
- Örebro universitet,Institutionen för naturvetenskap och teknik
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- Önnberg, Anna, 1980- (författare)
- Örebro universitet,Institutionen för hälsovetenskap och medicin,Department of Laboratory Medicine, Clinical Microbiology, Örebro University Hospital, Örebro, Sweden
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- Söderquist, Bo, 1955- (författare)
- Örebro universitet,Institutionen för läkarutbildning,Department of Laboratory Medicine, Clinical Microbiology, Örebro University Hospital, Örebro, Sweden
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- Persson, Katarina, 1962- (författare)
- Örebro universitet,Institutionen för hälsovetenskap och medicin
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(creator_code:org_t)
- London, United Kingdom : BioMed Central, 2013
- 2013
- Engelska.
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Ingår i: BMC Microbiology. - London, United Kingdom : BioMed Central. - 1471-2180. ; 13
- Relaterad länk:
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https://doi.org/10.1...
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https://bmcmicrobiol...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Background: Infections caused by extended spectrum beta-lactamases (ESBL)-producing bacteria have been emerging worldwide and the majority of ESBL-producing E. coli strains are isolated from patients with urinary tracts infections. The purpose of this study was to compare the host-response mechanisms in human polymorphonucleated leukocytes (PMN) and renal epithelial cells when stimulated by ESBL-or non-ESBL-producing uropathogenic E. coli (UPEC) isolates. The host-pathogen interaction of these ESBL-producing strains in the urinary tract is not well studied.Results: The ability of ESBL strains to evoke ROS-production from PMN cells was significantly higher than that of the non-ESBL strains. The growth of ESBL strains was slightly suppressed in the presence of PMN compared to non-ESBL strains after 30 min and 2 h, but the opposite was observed after 5 and 6 h. The number of migrating PMN was significantly higher in response to ESBL strains compared to non-ESBL strains. Stimulation of A498 cells with ESBL strains elicited lower production of IL-6 and IL-8 compared to non-ESBL strains.Conclusion: Significant differences in host-response mechanisms were identified when host cells were stimulated by ESBL-or non-ESBL producing strains. The obtained results on the early interactions of ESBL-producing strains with the host immune system may provide valuable information for management of these infections.
Ämnesord
- NATURVETENSKAP -- Biologi -- Mikrobiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Microbiology (hsv//eng)
Nyckelord
- Extended spectrum beta-lactamases
- Urinary tract infections
- Renal epithelial cells
- Polymorphonucleated leukocytes
- Uropathogenic E. coli
- Medicin
- Medicine
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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