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The antiviral cytom...
The antiviral cytomegalovirus inducible gene 5/viperin is expressed in atherosclerosis and regulated by proinflammatory agents
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- Olofsson, Peder (författare)
- Karolinska Institutet,Karolinska Institutet, Stockholm, Sweden
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- Jatta, Ken (författare)
- Örebro universitet,Institutionen för klinisk medicin,University of Örebro, Sweden
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- Wågsäter, Dick (författare)
- University of Örebro, Sweden
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- Gredmark, Sara (författare)
- Karolinska Institutet,Karolinska Institutet, Stockholm, Sweden
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- Hedin, Ulf (författare)
- Karolinska Institutet,Karolinska Institutet, Stockholm, Sweden
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- Paulsson-Berne, Gabrielle (författare)
- Karolinska Institutet,Karolinska Institutet, Stockholm, Sweden
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- Söderberg-Nauclér, Cecilia (författare)
- Karolinska Institutet,Karolinska Institutet, Stockholm, Sweden
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- Hansson, Göran (författare)
- Karolinska Institutet,Karolinska Institutet, Stockholm, Sweden
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- Sirsjö, Allan (författare)
- Örebro universitet,Institutionen för klinisk medicin,University of Örebro, Sweden
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(creator_code:org_t)
- American Heart Association, 2005
- 2005
- Engelska.
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Ingår i: Arteriosclerosis, Thrombosis and Vascular Biology. - : American Heart Association. - 1079-5642 .- 1524-4636. ; 25:7, s. 113-116
- Relaterad länk:
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https://doi.org/10.1...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- OBJECTIVE:Inflammatory processes play an important role in atherosclerosis, and increasing evidence implies that microbial pathogens and proinflammatory cytokines are involved in the development and activation of atherosclerotic lesions. To find new inflammatory genes, we explored the vascular transcriptional response to an activator of innate immunity bacterial lipopolysaccharides (LPSs).METHODS AND RESULTS:Gene arrays identified the cytomegalovirus-inducible gene 5 (cig5)/viperin among the genes most potently induced by LPS in human vascular biopsies. Viperin was expressed by endothelial cells in atherosclerotic arteries and significantly elevated in atherosclerotic compared with normal arteries. In culture, cytomegalovirus infection, interferon-gamma, and LPS induced viperin expression.CONCLUSIONS:Viperin is expressed in atherosclerosis and induced in vascular cells by inflammatory stimuli and cytomegalovirus infection. The putative functions of viperin in atherosclerosis may relate to disease-associated microbes.
Nyckelord
- MEDICINE
- MEDICIN
- Biomedicin
- Biomedicine
- atherosclerosis; gene expression; cytomegalovirus; inflammation; viperin
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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