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Physical performanc...
Physical performance and muscular characteristics in different stages of COPD
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- Eliason, Gabriella (författare)
- Örebro universitet,Hälsoakademin
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- Abdel-Halim, S. (författare)
- Örebro universitet,Hälsoakademin
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Arvidsson, B. (författare)
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- Kadi, Fawzi, 1970- (författare)
- Örebro universitet,Institutionen för hälsovetenskap och medicin,RISPA- MEP-RG
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- Piehl-Aulin, Karin (författare)
- Karolinska Institutet,Örebro universitet,Hälsoakademin
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(creator_code:org_t)
- Wiley-Blackwell Publishing Inc. 2009
- 2009
- Engelska.
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Ingår i: Scandinavian Journal of Medicine and Science in Sports. - : Wiley-Blackwell Publishing Inc.. - 0905-7188 .- 1600-0838. ; 19:6, s. 865-870
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- This study has examined exercise capacity and muscle morphology in patients with different severities of chronic obstructive pulmonary disease (COPD). Twenty-three patients and 12 healthy matched controls were recruited. Based on the severity of airflow obstruction, patients were divided into two subgroups. Exercise capacity was determined using a 6-min walk test. Muscle fiber composition, fiber area and number of satellite cells/muscle fiber were determined in muscle biopsies using immunohistochemistry. A progressive decline in exercise capacity was noted with ascending disease severity. Furthermore, a correlation between reduction in exercise capacity and changes in muscle fiber composition was observed in COPD. The group with severe and very severe COPD had a lower proportion of type I and a higher proportion of type IIa fibers compared with the other groups. In severe and very severe COPD, a reduction in fiber area of type IIa fibers was also seen. The number of satellite cells/muscle fiber did not differ between the groups. In conclusion, a decline in exercise capacity occurs already in mild and moderate COPD, indicating that the 6-min walk test is a reliable indicator of disease severity. Furthermore, changes in skeletal muscle morphology are associated with disease severity while muscle regenerative capacity is not altered.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Fysiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Physiology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Lungmedicin och allergi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Respiratory Medicine and Allergy (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Idrottsvetenskap (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Sport and Fitness Sciences (hsv//eng)
Nyckelord
- Activities of Daily Living/*psychology
- Adaptation; Psychological
- Aged
- Aged; 80 and over
- Attitude to Health
- Body Image
- Dependency (Psychology)
- Female
- Health Services Needs and Demand
- Humans
- Interpersonal Relations
- Male
- Middle Aged
- Models; Psychological
- Neoplasms/psychology
- Nursing Methodology Research
- Palliative Care/methods/*psychology
- Power (Psychology)
- Quality of Life/psychology
- Questionnaires
- Respite Care/psychology
- Self Concept
- Social Support
- Sweden
- MEDICINE
- MEDICIN
- Physiology
- Fysiologi
- Lung diseases
- Lungsjukdomar
- Sports
- Idrott
- Fysiologi
- Physiology
- Idrottsvetenskap
- Sports Science
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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