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Intraperitoneal met...
Intraperitoneal metabolic consequences of supra-celiac aortic balloon occlusion versus superior mesenteric artery occlusion : an experimental animal study utilising microdialysis
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- Hörer, Tal M., 1971- (författare)
- Örebro universitet,Institutionen för hälsovetenskap och medicin,Department of Cardio-Thoracic and Vascular Surgery, Örebro University Hospital, Sweden
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- Skoog, Per, 1975- (författare)
- Örebro universitet,Institutionen för hälsovetenskap och medicin,Department of Cardio-Thoracic and Vascular Surgery, Örebro University Hospital, Sweden
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- Nilsson, Kristofer F. (författare)
- Department of Cardio-Thoracic and Vascular Surgery, Örebro University and Örebro University Hospital, Sweden
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- Oikinomakis, Ioannis (författare)
- Department of Surgery Örebro University and Örebro University Hospital, Sweden
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- Larzon, Thomas, 1950- (författare)
- Örebro universitet,Institutionen för hälsovetenskap och medicin,Department of Cardio-Thoracic and Vascular Surgery, Örebro University and Örebro University Hospital, Sweden
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- Norgren, Lars, 1942- (författare)
- Örebro universitet,Hälsoakademin,Department of Surgery Örebro University and Örebro University Hospital, Sweden
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- Jansson, Kjell (författare)
- Department of Surgery Örebro University and Örebro University Hospital, Sweden
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(creator_code:org_t)
- Engelska.
- Relaterad länk:
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https://urn.kb.se/re...
Abstract
Ämnesord
Stäng
- Objective: To investigate the effect of aortic supra-celiac balloon occlusion (ABO) and superior mesenteric artery (SMA) occlusion on abdominal visceral metabolism in an animal model by using intraperitoneal microdialysis (IPM) and laser Doppler flowmetry. Design: Prospective study in pigsMaterial and methods: Nine pigs were subjected to ABO and seven animals were subjected to SMA occlusion for one hour followed by three hours of reperfusion. Seven animals served as controls. Hemodynamic data, arterial blood samples, urinary output and intestinal mucosal blood flow (IBF) were followed hourly. Intraperitoneal (i.p) glucose, glycerol, lactate and pyruvate concentrations and lactate-pyruvate (l/p) ratio were measured by IPM.Results: Compared to baseline, ABO reduced IBF by 76% and decreased urinary output. SMA occlusion reduced IBF by 75% without affecting urinary output. ABO increased the i.p l/p ratio from 18 at baseline, peaking at 46 in early reperfusion. SMA occlusion and reperfusion tended to increase the i.p l/p ratio, peaking at 36 in early reperfusion. ABO increased the i.p glycerol concentration from 87 μM at baseline to 579 μM after three hours of reperfusion. SMA occlusion and reperfusion increased the i.p glycerol concentration but to a lesser degree.Conclusions: Supra-celiac ABO caused severe hemodynamic, renal and systemic metabolic disturbances compared to SMA occlusion, most likely due to the more extensive ischemiareperfusion injury. The intra-abdominal metabolism, measured by microdialysis, was affected both by ABO and SMA occlusion but the most severe disturbances were caused by ABO. The i.p l/p ratios and the glycerol concentrations increased during ischemia and reperfusion and may serve as markers of these events and indicate anaerobic metabolism and cell damage respectively.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kirurgi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Surgery (hsv//eng)
Nyckelord
- Kirurgi
- Surgery
Publikations- och innehållstyp
- vet (ämneskategori)
- ovr (ämneskategori)
- Av författaren/redakt...
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Hörer, Tal M., 1 ...
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Skoog, Per, 1975 ...
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Nilsson, Kristof ...
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Oikinomakis, Ioa ...
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Larzon, Thomas, ...
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Norgren, Lars, 1 ...
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visa fler...
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Jansson, Kjell
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visa färre...
- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Kirurgi
- Av lärosätet
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Örebro universitet