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Intraperitoneal Met...
Intraperitoneal Metabolic Consequences of Supraceliac Aortic Balloon Occlusion in an Experimental Animal Study Using Microdialysis
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- Hörer, Tal M., 1971- (författare)
- Örebro universitet,Institutionen för hälsovetenskap och medicin,Region Örebro län,Department of Cardio-Thoracic and Vascular Surgery, Örebro University Hospital, Örebro, Sweden
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- Skoog, Per, 1975- (författare)
- Örebro universitet,Institutionen för hälsovetenskap och medicin,Department of Cardio-Thoracic and Vascular Surgery, Örebro University Hospital, Örebro, Sweden
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- Nilsson, Kristofer F., 1981- (författare)
- Örebro universitet,Institutionen för medicinska vetenskaper,Region Örebro län,Department of Cardio-Thoracic and Vascular Surgery, Örebro University Hospital, Örebro, Sweden
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- Oikonomakis, Ioannis, 1977- (författare)
- Department of Surgery, Örebro University Hospital, Örebro, Sweden
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- Larzon, Thomas, 1950- (författare)
- Örebro universitet,Institutionen för hälsovetenskap och medicin,Region Örebro län,Department of Cardio-Thoracic and Vascular Surgery, Örebro University Hospital, Örebro, Sweden
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- Norgren, Lars, 1942- (författare)
- Örebro universitet,Hälsoakademin,Department of Surgery, Örebro University Hospital, Örebro, Sweden
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- Jansson, Kjell (författare)
- Department of Surgery, Örebro University Hospital, Örebro, Sweden
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(creator_code:org_t)
- Elsevier, 2014
- 2014
- Engelska.
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Ingår i: Annals of Vascular Surgery. - : Elsevier. - 0890-5096 .- 1615-5947. ; 28:5, s. 1286-1295
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Background: To investigate the effects of supraceliac aortic balloon occlusion (ABO) and superior mesenteric artery (SMA) occlusion on abdominal visceral metabolism in an animal model using intraperitoneal microdialysis (IPM) and laser Doppler flowmetry.Methods: A total of 9 pigs were subjected to ABO and 7 animals were subjected to SMA occlusion for 1 hour followed by 3 hours of reperfusion. Seven animals served as controls. Hemodynamic data, arterial blood samples, urinary output, and intestinal mucosal blood flow (IBF) were followed hourly. Intraperitoneal (i.p) glucose, glycerol, lactate, and pyruvate concentrations and lactate-to-pyruvate (lip) ratio were measured using IPM.Results: Compared with the baseline, ABO reduced IBF by 76% and decreased urinary output. SMA occlusion reduced IBF by 75% without affecting urinary output. ABO increased the i.p lip ratio from 18 at baseline, peaking at 46 in early reperfusion. SMA occlusion and reperfusion tended to increase the i.p lip ratio, peaking at 36 in early reperfusion. ABO increased the i.p glycerol concentration from 87 mu M at baseline to 579 p,M after 3 hours of reperfusion. SMA occlusion and reperfusion increased The i.p glycerol concentration but to a lesser degree.Conclusions: Supraceliac ABO caused severe hemodynamic, renal, and systemic metabolic disturbances compared with SMA occlusion, most likely because of the more extensive ischemia-reperfusion injury. The intra-abdominal metabolism, measured by microdialysis, was affected by both ABO and SMA occlusion but the most severe disturbances were caused by ABO. The i.p lip ratios and the glycerol concentrations increased during ischemia and reperfusion and may serve as markers of these events and indicate anaerobic metabolism and cell damages respectively.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kirurgi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Surgery (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Nyckelord
- Kirurgi
- Surgery
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Hörer, Tal M., 1 ...
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Skoog, Per, 1975 ...
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Nilsson, Kristof ...
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Oikonomakis, Ioa ...
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Larzon, Thomas, ...
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Norgren, Lars, 1 ...
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visa fler...
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Jansson, Kjell
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visa färre...
- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Kirurgi
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Kardiologi
- Artiklar i publikationen
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Annals of Vascul ...
- Av lärosätet
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Örebro universitet