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In vitro bioassays ...
In vitro bioassays for detecting dioxin-like activity : Application potentials and limits of detection, a review
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- Eichbaum, Kathrin (författare)
- Dept Ecosystem Anal, Inst Environm Res, Rheinisch-Westfälische Technische Hochschule (RWTH), Aachen, Germany
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- Brinkmann, Markus (författare)
- Dept Ecosystem Anal, Inst Environm Res, Rheinisch-Westfälische Technische Hochschule (RWTH), Aachen, Germany
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- Buchinger, Sebastian (författare)
- Dept Biochem G3, Fed Inst Hydrol BFG, Koblenz, Germany
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- Reifferscheid, Georg (författare)
- Dept Biochem G3, Fed Inst Hydrol BFG, Koblenz, Germany
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- Hecker, Markus (författare)
- Sch Environm & Sustainabil, Univ Saskatchewan, Saskatoon, Canada; Toxicol Ctr, Univ Saskatchewan, Saskatoon, Canada
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- Giesy, John P. (författare)
- School of the Environment and Sustainability and Toxicology Centre, University of Saskatchewan, Saskatoon, Canada; Department of Veterinary Biomedical Sciences and Toxicology Centre, University of Saskatchewan, Saskatoon, Canada; Department of Zoology and Center for Integrative Toxicology, Michigan State University, East Lansing MI, United States; Department of Biology and Chemistry, State Key Laboratory in Marine Pollution, City University of Hong Kong, Hong Kong, China; School of Biological Sciences, University of Hong Kong, Hong Kong, China
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- Engwall, Magnus, 1965- (författare)
- Örebro universitet,Institutionen för naturvetenskap och teknik
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- van Bavel, Bert, 1963- (författare)
- Örebro universitet,Institutionen för naturvetenskap och teknik
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- Hollert, Henner (författare)
- Institute for Environmental Research, Department of Ecosystem Analysis, Rheinisch-Westfälische Technische Hochschule (RWTH), Aachen University, Aachen, Germany; Key Laboratory of Yangtze River Environment of Education Ministry of China, College of Environmental Science and Engineering, Tongji University, Shanghai, China; College of Resources and Environmental Science, Chongqing University, Chongqing, China; School of Environment, Nanjing University, Nanjing, China
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(creator_code:org_t)
- Amsterdam : Elsevier, 2014
- 2014
- Engelska.
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Ingår i: Science of the Total Environment. - Amsterdam : Elsevier. - 0048-9697 .- 1879-1026. ; 487, s. 37-48
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Use of in vitro assays as screening tool to characterize contamination of a variety of environmental matrices has become an increasingly popular and powerful toolbox in the field of environmental toxicology.While bioassays cannot entirely substitute analytical methods such as gas chromatography-mass spectrometry (GC-MS), the increasing improvement of cell lines and standardization of bioassay procedures enhance their utility as bioanalytical pre-screening tests prior to more targeted chemical analytical investigations. Dioxin-receptor-based assays provide a holistic characterization of exposure to dioxin-like compounds (DLCs) by integrating their overall toxic potential, including potentials of unknown DLCs not detectable via e.g. GC-MS. Hence, they provide important additional information with respect to environmental risk assessment of DLCs.This review summarizes different in vitro bioassay applications for detection of DLCs and considers the comparability of bioassay and chemical analytically derived toxicity equivalents (TEQs) of different approaches and various matrices. These range from complex samples such as sediments through single reference to compound mixtures. A summary of bioassay derived detection limits (LODs) showed a number of current bioassays to be equally sensitive as chemical methodologies, but moreover revealed that most of the bioanalytical studies conducted to date did not report their LODs, which represents a limitation with regard to low potency samples.
Ämnesord
- NATURVETENSKAP -- Geovetenskap och miljövetenskap -- Miljövetenskap (hsv//swe)
- NATURAL SCIENCES -- Earth and Related Environmental Sciences -- Environmental Sciences (hsv//eng)
Nyckelord
- TEQ-approach
- LOD
- Dioxin
- Effect directed analysis
- Exposure characterization
- Enviromental Science
- Miljövetenskap
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Eichbaum, Kathri ...
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Brinkmann, Marku ...
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Buchinger, Sebas ...
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Reifferscheid, G ...
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Hecker, Markus
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Giesy, John P.
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Engwall, Magnus, ...
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van Bavel, Bert, ...
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Hollert, Henner
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Örebro universitet