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Sökning: id:"swepub:oai:DiVA.org:oru-42358" > Urinary melatonin l...

Urinary melatonin levels, sleep disruption, and risk of prostate cancer in elderly men

Sigurdardottir, Lara G. (författare)
Centre of Public Health Sciences, University of Iceland, Reykjavik, Iceland; Faculty of Medicine, University of Iceland, Reykjavik, Iceland; Icelandic Cancer Society, Reykjavik, Iceland
Markt, Sarah C. (författare)
Department of Epidemiology, Harvard School of Public Health, Boston MA, United States
Rider, Jennifer R. (författare)
Department of Epidemiology, Harvard School of Public Health, Boston MA, United States; Channing Division of Network Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston MA, United States
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Haneuse, Sebastien (författare)
Department of Biostatistics, Harvard School of Public Health, Boston MA, United States
Fall, Katja, 1971- (författare)
Örebro universitet,Institutionen för hälsovetenskap och medicin,Centre of Public Health Sciences, University of Iceland, Reykjavik, Iceland; Department of Epidemiology, Harvard School of Public Health, Boston MA, United States; Clinical Epidemiology Unit, Örebro University, Örebro University Hospital, Örebro, Sweden
Schernhammer, Eva S. (författare)
Department of Epidemiology, Harvard School of Public Health, Boston MA, United States; Channing Division of Network Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston MA, United States
Tamimi, Rulla M. (författare)
Department of Epidemiology, Harvard School of Public Health, Boston MA, United States; Channing Division of Network Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston,MA, United States
Flynn-Evans, Erin (författare)
Division of Sleep Medicine, Harvard Medical School, Boston MA, United States; Division of Sleep and Circadian Disorders, Departments of Medicine and Neurology, Brigham and Women's Hospital, Boston MA, United States
Batista, Julie L. (författare)
Department of Epidemiology, Harvard School of Public Health, Boston MA, United States; Channing Division of Network Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston MA, United States
Launer, Lenore (författare)
Laboratory of Epidemiology and Population Sciences, National Institute on Aging, Bethesda MD, United States
Harris, Tamara (författare)
Laboratory of Epidemiology and Population Sciences, National Institute on Aging, Bethesda MD, United States
Aspelund, Thor (författare)
Centre of Public Health Sciences, University of Iceland, Reykjavik, Iceland; Icelandic Heart Association, Kopavogur, Iceland
Stampfer, Meir J. (författare)
Department of Epidemiology, Harvard School of Public Health, Boston MA, United States; Channing Division of Network Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston MA, United States
Gudnason, Vilmundur (författare)
Faculty of Medicine, University of Iceland, Reykjavik, Iceland; Icelandic Heart Association, Kopavogur, Iceland
Czeisler, Charles A. (författare)
Division of Sleep Medicine, Harvard Medical School, Boston MA, United States; Division of Sleep and Circadian Disorders, Departments of Medicine and Neurology, Brigham and Women's Hospital, Boston MA, United States
Lockley, Steven W. (författare)
Division of Sleep Medicine, Harvard Medical School, Boston MA, United States; Division of Sleep and Circadian Disorders, Departments of Medicine and Neurology, Brigham and Women's Hospital, Boston MA, United States
Valdimarsdottir, Unnur A. (författare)
Centre of Public Health Sciences, University of Iceland, Reykjavik, Iceland; Faculty of Medicine, University of Iceland, Reykjavik, Iceland; Department of Epidemiology, Harvard School of Public Health, Boston MA, United States
Mucci, Lorelei A. (författare)
Centre of Public Health Sciences, University of Iceland, Reykjavik, Iceland; Department of Epidemiology, Harvard School of Public Health, Boston MA, United States; Channing Division of Network Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston MA, United States
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 (creator_code:org_t)
Elsevier, 2015
2015
Engelska.
Ingår i: European Urology. - : Elsevier. - 0302-2838 .- 1873-7560. ; 67:2, s. 191-194
Relaterad länk:
https://www.hirsla.l...
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https://urn.kb.se/re...
https://doi.org/10.1...
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  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
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  • Melatonin has anticarcinogenic properties in experimental models. We undertook a case-cohort study of 928 Icelandic men without prostate cancer (PCa) nested within the Age, Gene/Environment Susceptibility (AGES)-Reykjavik cohort to investigate the prospective association between first morning-void urinary 6-sulfatoxymelatonin (aMT6s) levels and the subsequent risk for PCa, under the hypothesis that men with lower aMT6s levels have an increased risk for advanced PCa. We used weighted Cox proportional hazards models to assess the association between first morning-void aMT6s levels and PCa risk, adjusting for potential confounders. A total of 111 men were diagnosed with incident PCa, including 24 with advanced disease. Men who reported sleep problems at baseline had lower morning aMT6s levels compared with those who reported no sleep problems. Men with morning aMT6s levels below the median had a fourfold statistically significant increased risk for advanced disease compared with men with levels above the median (hazard ratio: 4.04; 95% confidence interval, 1.26-12.98). These results require replication in larger prospective studies with longer follow-up.Patient summary: In this report, we evaluated the prospective association between urinary aMT6s levels and risk of PCa in an Icelandic population. We found that lower levels of aMT6s were associated with an increased risk for advanced PCa.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Urologi och njurmedicin (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Urology and Nephrology (hsv//eng)

Nyckelord

Circadian rhythm
Melatonin levels
Prostate cancer
Medicine
Medicin

Publikations- och innehållstyp

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art (ämneskategori)

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