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Stress-Related Signaling Pathways in Lethal and Nonlethal Prostate Cancer

Lu, Donghao (författare)
Karolinska Institutet,Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden.
Sinnott, Jennifer A. (författare)
Department of Statistics, Ohio State University, Columbus OH, USA; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, USA,Ohio State Univ, Dept Stat, 1958 Neil Ave, Columbus, OH 43210 USA.;Harvard Univ, Dept Epidemiol, TH Chan Sch Publ Hlth, Boston, MA 02115 USA.
Valdimarsdóttir, Unnur (författare)
Karolinska Institutet,Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden.;Harvard Univ, Dept Epidemiol, TH Chan Sch Publ Hlth, Boston, MA 02115 USA.;Univ Iceland, Sch Hlth Sci, Ctr Publ Hlth Sci, Fac Med, Reykjavik, Iceland.
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Fang, Fang (författare)
Karolinska Institutet,Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden.
Gerke, Travis (författare)
Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, USA; Department of Epidemiology, College of Medicine and College of Public Health and Health Professions, University of Florida, Gainesville, USA,Harvard Univ, Dept Epidemiol, TH Chan Sch Publ Hlth, Boston, MA 02115 USA.;Univ Florida, Coll Med, Dept Epidemiol, Gainesville, FL USA.;Univ Florida, Coll Publ Hlth & Hlth Profess, Gainesville, FL USA.
Tyekucheva, Svitlana (författare)
Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute, Boston, USA,Dana Farber Canc Inst, Dept Biostat & Computat Biol, Boston, MA 02115 USA.
Fiorentino, Michelangelo (författare)
Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, USA; Center for Molecular Oncologic Pathology, Dana-Farber Cancer Institute, Boston, USA; Pathology Unit, Addarii Institute, S. Orsola-Malpighi Hospital, Bologna, Italy,Harvard Univ, Dept Epidemiol, TH Chan Sch Publ Hlth, Boston, MA 02115 USA.;Dana Farber Canc Inst, Ctr Mol Oncol Pathol, Boston, MA 02115 USA.;St Orsola Marcello Malpighi Hosp, Addarii Inst, Pathol Unit, Bologna, Italy.
Lambe, Mats (författare)
Uppsala universitet,Karolinska Institutet,Institutionen för medicinska vetenskaper,Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden.
Sesso, Howard D. (författare)
Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, USA; Division of Preventive Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, USA; Division of Aging, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, USA,Harvard Univ, Dept Epidemiol, TH Chan Sch Publ Hlth, Boston, MA 02115 USA.;Brigham & Womens Hosp, Dept Med, Div Prevent Med, 75 Francis St, Boston, MA 02115 USA.;Harvard Univ, Sch Med, Boston, MA USA.;Brigham & Womens Hosp, Dept Med, Div Aging, 75 Francis St, Boston, MA 02115 USA.
Sweeney, Christopher J. (författare)
Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, USA,Dana Farber Canc Inst, Dept Med Oncol, Boston, MA 02115 USA.
Wilson, Kathryn M. (författare)
Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, USA; Faculty of Medicine, Center of Public Health Sciences, School of Health Sciences, University of Iceland, Reykjavík, Iceland,Harvard Univ, Dept Epidemiol, TH Chan Sch Publ Hlth, Boston, MA 02115 USA.;Univ Iceland, Sch Hlth Sci, Ctr Publ Hlth Sci, Fac Med, Reykjavik, Iceland.
Giovannucci, Edward L. (författare)
Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, USA; Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, USA,Harvard Univ, Dept Epidemiol, TH Chan Sch Publ Hlth, Boston, MA 02115 USA.;Harvard Univ, Sch Med, Boston, MA USA.;Brigham & Womens Hosp, Channing Div Network Med, 75 Francis St, Boston, MA 02115 USA.
Loda, Massimo (författare)
Center for Molecular Oncologic Pathology, Dana-Farber Cancer Institute, Boston, USA; Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, USA,Dana Farber Canc Inst, Ctr Mol Oncol Pathol, Boston, MA 02115 USA.;Harvard Univ, Sch Med, Boston, MA USA.;Brigham & Womens Hosp, Dept Pathol, 75 Francis St, Boston, MA 02115 USA.
Mucci, Lorelei A. (författare)
Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, USA; Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, USA,Harvard Univ, Dept Epidemiol, TH Chan Sch Publ Hlth, Boston, MA 02115 USA.;Harvard Univ, Sch Med, Boston, MA USA.;Brigham & Womens Hosp, Channing Div Network Med, 75 Francis St, Boston, MA 02115 USA.
Fall, Katja, 1971- (författare)
Örebro universitet,Institutionen för medicinska vetenskaper,Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, USA; Department of Clinical Epidemology and Biostatistics, Örebro University Hospital, Örebro, Sweden,Harvard Univ, Dept Epidemiol, TH Chan Sch Publ Hlth, Boston, MA 02115 USA.;Univ Orebro, Clin Epidemiol & Biostat, Fac Med & Hlth, SE-70182 Orebro, Sweden.
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Karolinska Institutet Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden (creator_code:org_t)
Philadelphia, USA : American Association for Cancer Research, 2016
2016
Engelska.
Ingår i: Clinical cancer research : an official journal of the American Association for Cancer Research. - Philadelphia, USA : American Association for Cancer Research. - 1078-0432 .- 1557-3265. ; 22:3, s. 765-772
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https://doi.org/10.1...
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  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
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  • Purpose: Recent data suggest that neuroendocrine signaling may influence progression in some cancers. We aimed to determine whether genes within the five major stress-related signaling pathways are differentially expressed in tumor tissue when comparing prostate cancer patients with lethal and nonlethal disease.Experimental design: We measured mRNA expression of 51 selected genes involved in predetermined stress-related signaling pathways (adrenergic, glucocorticoid, dopaminergic, serotoninergic, and muscarinic systems) in tumor tissue and normal prostate tissue collected from prostate cancer patients in the Physicians' Health Study (n = 150; n = 82 with normal) and the Health Professionals Follow-Up Study (n = 254; n = 120 with normal). We assessed differences in pathway expression in relation to prostate cancer lethality as the primary outcome and to biomarkers as secondary outcomes.Results: Differential mRNA expression of genes within the adrenergic (P = 0.001), glucocorticoid (P < 0.0001), serotoninergic (P = 0.0019), and muscarinic (P = 0.0045) pathways in tumor tissue was associated with the risk of lethality. The adrenergic pathway was also statistically significant (P = 0.001) when comparing against differential expression of genes not involved in the pathways. In adjacent normal prostate tissue, none of the pathways was clearly differentially expressed between lethal and nonlethal prostate cancer. The glucocorticoid and adrenergic pathways were associated with cell proliferation, while the glucocorticoid pathway was additionally associated with angiogenesis and perineural invasion.Conclusions: Our study suggests that stress-related signaling pathways, particularly the adrenergic and glucocorticoid, may be dysregulated in the tumors of men whose prostate cancer proves to be lethal, and motivates further investigation of these pathways in functional studies.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Cancer and Oncology (hsv//eng)

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Onkologi
Oncology

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