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Safety of probiotic...
Safety of probiotics and synbiotics in children under 18 years of age
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- van den Nieuwboer, M. (author)
- Athena Institute, Vrije University, Amsterdam, the Netherlands
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- Brummer, Robert Jan, 1957- (author)
- Örebro universitet,Institutionen för läkarutbildning
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- Guarner, F. (author)
- Digestive System Research Unit, CIBERehd, University Hospital Vall d’Hebron, Barcelona, Spain
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- Morelli, L. (author)
- Istituto di Microbiologia, Università Cattolica S.C., Piacenza, Italy
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- Cabana, M. (author)
- Departments of Pediatrics, Epidemiology and Biostatistics, University of California (UCSF), San Francisco, USA
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- Claassen, E. (author)
- Athena Institute, Vrije University, Amsterdam, the Netherlands; Department of Viroscience, Erasmus Medical Center, Rotterdam, the Netherlands
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(creator_code:org_t)
- Wageningen Academic Publishers, 2015
- 2015
- English.
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In: Beneficial Microbes. - : Wageningen Academic Publishers. - 1876-2883 .- 1876-2891. ; 6:5, s. 615-630
- Related links:
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https://doi.org/10.3...
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https://urn.kb.se/re...
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https://doi.org/10.3...
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Abstract
Subject headings
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- This study aimed to systematically evaluate safety of probiotics and synbiotics in children ageing 0-18 years. This study is the third and final part in a safety trilogy and an update is provided using the most recent available clinical data (2008-2013) by means of the Common Terminology Clinical Adverse Events (CTCAE version 4.0) classification. Safety aspects are represented and related to number of participants per probiotic strain/culture, study duration, dosage, clinical condition and selected afflictions. Analysis of 74 clinical studies indicated that probiotic and/or synbiotic administration in children is safe with regard to the specific evaluated strains, dosages and duration. The population of children include healthy, immune compromised and obese subjects, as well as subjects with intestinal disorders, infections and inflammatory disorders. This study revealed no major safety concerns, as the adverse events (AEs) were unrelated, or not suspected to be related, to the probiotic or synbiotic product. In general the study products were well tolerated. Overall, AEs occurred more frequent in the control arm compared to children receiving probiotics and/or synbiotics. Furthermore, the results indicate inadequate reporting and classification of AEs in the majority of the studies. In addition, generalizability of conclusions are greatly limited by the inconsistent, imprecise and potentially incomplete reporting as well as the variation in probiotic strains, dosages, administration regimes, study populations and reported outcomes.
Subject headings
- NATURVETENSKAP -- Biologi -- Mikrobiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Microbiology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Näringslära (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Nutrition and Dietetics (hsv//eng)
Keyword
- probiotics
- synbiotics
- children
- safety
- prebiotics
- Microbiology
- Mikrobiologi
- Nutrition
- Näringslära
Publication and Content Type
- ref (subject category)
- art (subject category)
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