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Activated T cells i...
Activated T cells in the nasal mucosa of patients with grass-pollen allergy. A pilot study
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- Hellquist, H. B. (författare)
- Örebro Medical Center, Örebro, Sweden
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- Karlsson, Mats G., 1960- (författare)
- Örebro Medical Center, Örebro, Sweden
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Rudblad, S. (författare)
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visa fler...
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Ekedahl, C. (författare)
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- Davidsson, Åke, 1956- (författare)
- Örebro Medical Center, Örebro, Sweden
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visa färre...
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(creator_code:org_t)
- Amsterdam, Netherlands : International Rhinologic Society, 1992
- 1992
- Engelska.
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Ingår i: Rhinology. - Amsterdam, Netherlands : International Rhinologic Society. - 0300-0729 .- 1996-8604. ; 30:1, s. 57-63
- Relaterad länk:
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https://urn.kb.se/re...
Abstract
Ämnesord
Stäng
- Six patients with grass-pollen allergy were provoked with water-soluble grass pollen until a pronounced allergic reaction occurred. This was performed outside the grass-pollen season, and the allergen was administered on the edge of the inferior turbinate. Biopsies were taken both before provocation and during the reaction, 15-30 minutes after provocation. The nasal population of immunohistochemically positive cells for HLA-DR, CD1, interleukin-2-receptor, IgE, CD4 and CD8 were studied. There was a marked increase of IL2-R-positive cells (activated T lymphocytes) in the nasal mucosa after provocation, whilst the other cell populations approximately remained unchanged (apart from a certain increase of IgE). The increase of activated T lymphocytes may imply that certain subsets of T cells play a role in the allergic response, and that the role of helper T cells very likely is much more complex than the regulation of mast cells and eosinophils. The concomitant presence of Langerhans' cells (CD1-positive) and activated T lymphocytes may indicate a possible association on site between an antigen-presenting cell and both effector as well as memory cells in allergic reactions.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Klinisk laboratoriemedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Clinical Laboratory Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Lungmedicin och allergi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Respiratory Medicine and Allergy (hsv//eng)
Nyckelord
- Biomedicin
- Biomedicine
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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