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Stent Thrombosis in...
Stent Thrombosis in New-Generation Drug-Eluting Stents in Patients With STEMI Undergoing Primary PCI
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- Sarno, Giovanna (författare)
- Uppsala universitet,Uppsala kliniska forskningscentrum (UCR)
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- Lagerqvist, Bo (författare)
- Uppsala universitet,Kardiologi
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- Nilsson, Johan (författare)
- Umeå universitet,Kardiologi,Heart Centre
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- Fröbert, Ole, 1964- (författare)
- Region Örebro län,Department of Cardiology, Örebro University Hospital, Örebro, Sweden
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- Hambraeus, Kristina (författare)
- Dept Cardiol, Falun Cent Hosp, Falun, Sweden,Falun Central Hospital, Sweden
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- Varenhorst, Christoph (författare)
- Uppsala universitet,Uppsala kliniska forskningscentrum (UCR)
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- Jensen, Ulf J. (författare)
- Karolinska Institutet
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- Tödt, Tim (författare)
- Östergötlands Läns Landsting,Linköpings universitet,Avdelningen för kardiovaskulär medicin,Hälsouniversitetet,Kardiologiska kliniken US
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- Götberg, Matthias (författare)
- Lund University,Lunds universitet,Kardiologi,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Cardiology,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Dept Cardiol, Lund Univ, Lund, Sweden,Lund University, Sweden
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- James, Stefan K. (författare)
- Uppsala universitet,Kardiologi,Uppsala kliniska forskningscentrum (UCR)
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(creator_code:org_t)
- Elsevier, 2014
- 2014
- Engelska.
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Ingår i: Journal of the American College of Cardiology. - : Elsevier. - 0735-1097 .- 1558-3597. ; 64:1, s. 16-24
- Relaterad länk:
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https://doi.org/10.1...
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http://www.ncbi.nlm....
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http://dx.doi.org/10...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://lup.lub.lu.s...
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https://urn.kb.se/re...
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http://kipublication...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- BACKGROUND: Some concerns still have not been resolved about the long-term safety of drug-eluting stents (DES) in patients with acute STEMI.OBJECTIVES: The aim of this study was to evaluate the stent thrombosis (ST) rate up to 3 years in patients with ST-segment elevation myocardial infarction (STEMI) treated by primary percutaneous coronary intervention (PCI) with new-generation drug-eluting stents (n-DES) compared with bare-metal stents (BMS) and old-generation drug-eluting stents (o-DES) enrolled in the SCAAR (Swedish Coronary Angiography and Angioplasty Registry).METHODS: From January 2007 to January 2013, 34,147 patients with STEMI were treated by PCI with n-DES (n = 4,811), o-DES (n = 4,271), or BMS (n = 25,065). The risks of early/late (up to 1 year) and very late definite ST (after 1 year) were estimated.RESULTS: Cox regression landmark analysis showed a significantly lower risk of early/late ST in patients treated with n-DES (hazard ratio [HR]: 0.65; 95% confidence interval [CI]: 0.43 to 0.99; p 0.04) and o-DES (HR: 0.60; 95% CI: 0.41 to 0.89; p = 0.01) compared with the BMS group. The risk of very late ST was similar between the n-DES and BMS groups (HR: 1.52; 95% CI: 0.78 to 2.98; p = 0.21), whereas a higher risk of very late ST was observed with o-DES compared with BMS (HR: 2.88; 95% CI: 1.70 to 4.89; p < 0.01).CONCLUSIONS: Patients treated with n-DES have a lower risk of early/late ST than patients treated with BMS. The risk of very late ST is low and comparable between n-DES and BMS up to 3 years of follow-up, whereas o-DES treatment is associated with an increased risk of very late ST. The current STEMI guidelines might require an update in light of the results of this and other recent studies. (C) 2014 by the American College of Cardiology Foundation.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
Nyckelord
- drug-eluting stent(s)
- percutaneous coronary intervention
- ST-segment elevation myocardial infarction
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Sarno, Giovanna
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Lagerqvist, Bo
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Nilsson, Johan
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Fröbert, Ole, 19 ...
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Hambraeus, Krist ...
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Varenhorst, Chri ...
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visa fler...
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Jensen, Ulf J.
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Tödt, Tim
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Götberg, Matthia ...
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James, Stefan K.
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- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Kardiologi
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
- Artiklar i publikationen
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Journal of the A ...
- Av lärosätet
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Örebro universitet
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Lunds universitet
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Linköpings universitet
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Karolinska Institutet
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Umeå universitet
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Uppsala universitet