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Prolonged sleep res...
Prolonged sleep restriction induces changes in pathways involved in cholesterol metabolism and inflammatory responses
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- Aho, Vilma (författare)
- Department of Physiology, Faculty of Medicine, University of Helsinki, Helsinki, Finland
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- Ollila, Hanna M (författare)
- Department of Physiology, Faculty of Medicine, University of Helsinki, Helsinki, Finland; Genomics and Biomarkers Unit, Institute for Molecular Medicine FIMM, National Institute for Health and Welfare, Helsinki, Finland; Department of Psychiatry, Helsinki University Hospital, University of Helsinki, Helsinki, Finland; Stanford University Center for Sleep Sciences, Palo Alto CA, United States
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- Kronholm, Erkki (författare)
- Department of Chronic Disease Prevention, Population Studies Unit, National Institute for Health and Welfare, Turku, Finland
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- Bondia-Pons, Isabel (författare)
- VTT Technical Research Centre of Finland, Espoo, Finland; Steno Diabetes Center A/S, Gentofte, Denmark
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- Soininen, Pasi (författare)
- Computational Medicine, Institute of Health Sciences, University of Oulu, Oulu, Finland; NMR Metabolomics Laboratory, School of Pharmacy, University of Eastern Finland, Kuopio, Finland
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- Kangas, Antti J (författare)
- Computational Medicine, Institute of Health Sciences, University of Oulu, Oulu, Finland
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- Hilvo, Mika (författare)
- VTT Technical Research Centre of Finland, Espoo, Finland
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- Seppälä, Ilkka (författare)
- Department of Clinical Chemistry, Fimlab Laboratories, University of Tampere, School of Medicine, Tampere, Finland
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- Kettunen, Johannes (författare)
- Genomics and Biomarkers Unit, Institute for Molecular Medicine FIMM, National Institute for Health and Welfare, Helsinki, Finland; Computational Medicine, Institute of Health Sciences, University of Oulu, Oulu, Finland; NMR Metabolomics Laboratory, School of Pharmacy, University of Eastern Finland, Kuopio, Finland
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- Oikonen, Mervi (författare)
- Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland
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- Raitoharju, Emma (författare)
- Department of Clinical Chemistry, Fimlab Laboratories, University of Tampere, School of Medicine, Tampere, Finland
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- Hyötyläinen, Tuulia, 1971- (författare)
- Örebro universitet,Institutionen för naturvetenskap och teknik,VTT Technical Research Centre of Finland, Espoo, Finland; Steno Diabetes Center A/S, Gentofte, Denmark
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- Kähönen, Mika (författare)
- Department of Clinical Physiology, University of Tampere, Tampere University Hospital, Tampere, Finland
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- Viikari, Jorma S A (författare)
- Department of Medicine, University of Turku, Turku, Finland; Division of Medicine, Turku University Hospital, Turku, Finland
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- Härmä, Mikko (författare)
- Brain and Work Research Centre, Finnish Institute of Occupational Health, Helsinki, Finland
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- Sallinen, Mikael (författare)
- Brain and Work Research Centre, Finnish Institute of Occupational Health, Helsinki, Finland; Agora Center, University of Jyväskylä, Jyväskylä, Finland
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- Olkkonen, Vesa M (författare)
- Minerva Foundation Institute for Medical Research, Helsinki, Finland; Institute of Biomedicine, Anatomy, University of Helsinki, Helsinki, Finland
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- Alenius, Harri (författare)
- Unit of Excellence for Immunotoxicology, Finnish Institute of Occupational Health, Helsinki, Finland
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- Jauhiainen, Matti (författare)
- Genomics and Biomarkers Unit, Institute for Molecular Medicine FIMM, National Institute for Health and Welfare, Helsinki, Finland
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- Paunio, Tiina (författare)
- Genomics and Biomarkers Unit, Institute for Molecular Medicine FIMM, National Institute for Health and Welfare, Helsinki, Finland; Department of Psychiatry, Helsinki University Hospital, University of Helsinki, Helsinki, Finland
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- Lehtimäki, Terho (författare)
- Department of Clinical Chemistry, Fimlab Laboratories, University of Tampere, School of Medicine, Tampere, Finland
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- Salomaa, Veikko (författare)
- Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki, Finland
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- Orešič, Matej, 1967- (författare)
- VTT Technical Research Centre of Finland, Espoo, Finland; Steno Diabetes Center A/S, Gentofte, Denmark
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- Raitakari, Olli T (författare)
- Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland; Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, Turku, Finland
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- Ala-Korpela, Mika (författare)
- Computational Medicine, Institute of Health Sciences, University of Oulu, Oulu, Finland; NMR Metabolomics Laboratory, School of Pharmacy, University of Eastern Finland, Kuopio, Finland; Oulu University Hospital, Oulu, Finland; Computational Medicine, School of Social and Community Medicine, Medical Research Council Integrative Epidemiology Unit, University of Bristol, Bristol, United Kingdom
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- Porkka-Heiskanen, Tarja (författare)
- Department of Physiology, Faculty of Medicine, University of Helsinki, Helsinki, Finland
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(creator_code:org_t)
- 2016-04-22
- 2016
- Engelska.
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Ingår i: Scientific Reports. - : Nature Publishing Group. - 2045-2322. ; 6
- Relaterad länk:
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https://doi.org/10.1...
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https://www.nature.c...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Sleep loss and insufficient sleep are risk factors for cardiometabolic diseases, but data on how insufficient sleep contributes to these diseases are scarce. These questions were addressed using two approaches: an experimental, partial sleep restriction study (14 cases and 7 control subjects) with objective verification of sleep amount, and two independent epidemiological cohorts (altogether 2739 individuals) with questions of sleep insufficiency. In both approaches, blood transcriptome and serum metabolome were analysed. Sleep loss decreased the expression of genes encoding cholesterol transporters and increased expression in pathways involved in inflammatory responses in both paradigms. Metabolomic analyses revealed lower circulating large HDL in the population cohorts among subjects reporting insufficient sleep, while circulating LDL decreased in the experimental sleep restriction study. These findings suggest that prolonged sleep deprivation modifies inflammatory and cholesterol pathways at the level of gene expression and serum lipoproteins, inducing changes toward potentially higher risk for cardiometabolic diseases.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Annan klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Other Clinical Medicine (hsv//eng)
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- Av författaren/redakt...
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Aho, Vilma
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Ollila, Hanna M
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Kronholm, Erkki
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Bondia-Pons, Isa ...
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Soininen, Pasi
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Kangas, Antti J
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visa fler...
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Hilvo, Mika
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Seppälä, Ilkka
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Kettunen, Johann ...
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Oikonen, Mervi
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Raitoharju, Emma
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Hyötyläinen, Tuu ...
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Kähönen, Mika
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Viikari, Jorma S ...
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Härmä, Mikko
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Sallinen, Mikael
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Olkkonen, Vesa M
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Alenius, Harri
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Jauhiainen, Matt ...
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Paunio, Tiina
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Lehtimäki, Terho
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Salomaa, Veikko
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Orešič, Matej, 1 ...
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Raitakari, Olli ...
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Ala-Korpela, Mik ...
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Porkka-Heiskanen ...
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Örebro universitet