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Midlife metabolic f...
Midlife metabolic factors and prostate cancer risk in later life
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- Dickerman, Barbra A. (författare)
- Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston MA, USA
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- Torfadottir, Johanna E. (författare)
- Centre for Public Health Sciences, University of Iceland, Reykjavik, Iceland
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- Valdimarsdottir, Unnur A. (författare)
- Karolinska Institutet
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- Wilson, Kathryn M. (författare)
- Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston MA, USA; Centre for Public Health Sciences, University of Iceland, Reykjavik, Iceland; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
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- Steingrimsdottir, Laufey (författare)
- Unit for Nutrition Research, University Hospital, Reykjavik, Iceland; Faculty of Food Science and Nutrition, University of Iceland, Reykjavik, Iceland
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- Aspelund, Thor (författare)
- Centre for Public Health Sciences, University of Iceland, Reykjavik, Iceland; The Icelandic Heart Association, Kopavogur, Iceland
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- Batista, Julie L. (författare)
- Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston MA, USA;
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- Fall, Katja, 1971- (författare)
- Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston MA, USA,Clinical Epidemiology and Biostatistics
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- Giovannucci, Edward (författare)
- Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston MA, USA; Channing Division of Network Medicine, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston MA, USA; Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston MA, USA
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- Sigurdardottir, Lara G. (författare)
- Centre for Public Health Sciences, University of Iceland, Reykjavik, Iceland; Faculty of Medicine, University of Iceland, Reykjavik, Iceland; Department of Education and Prevention, The Icelandic Cancer Society, Reykjavik, Iceland
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- Tryggvadottir, Laufey (författare)
- The Icelandic Cancer Registry, Reykjavik, Iceland
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- Gudnason, Vilmundur (författare)
- The Icelandic Heart Association, Kopavogur, Iceland; Faculty of Medicine, University of Iceland, Reykjavik, Iceland
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- Markt, Sarah C. (författare)
- Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston MA, USA
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- Mucci, Lorelei A. (författare)
- Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston MA, USA; Channing Division of Network Medicine, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston MA, USA
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Department of Epidemiology, Harvard TH. Chan School of Public Health, Boston MA, USA Centre for Public Health Sciences, University of Iceland, Reykjavik, Iceland (creator_code:org_t)
- 2017-11-16
- 2018
- Engelska.
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Ingår i: International Journal of Cancer. - Hoboken, USA : John Wiley & Sons. - 0020-7136 .- 1097-0215. ; 142:6, s. 1166-1173
- Relaterad länk:
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https://onlinelibrar...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Metabolic syndrome is associated with several cancers, but evidence for aggressive prostate cancer is sparse. We prospectively investigated the influence of metabolic syndrome and its components on risk of total prostate cancer and measures of aggressive disease in a cohort of Icelandic men. Men in the Reykjavik Study (n = 9,097, enrolled 1967-1987) were followed for incident (n = 1,084 total; n = 378 advanced; n = 148 high-grade) and fatal (n = 340) prostate cancer until 2014. Cox regression was used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) for (1) measured metabolic factors at cohort entry (body mass index (BMI), blood pressure, triglycerides, fasting blood glucose) and (2) a metabolic syndrome score (range 0-4) combining the risk factors: BMI ≥30 kg/m2 ; systolic blood pressure (SBP) ≥130 or diastolic blood pressure (DBP) ≥85 mm Hg or taking antihypertensives; triglycerides ≥150 mg/dl; fasting blood glucose ≥100 mg/dl or self-reported type 2 diabetes. Hypertension and type 2 diabetes were associated with a higher risk of total, advanced, high-grade, and fatal prostate cancer, independent of BMI. Neither BMI nor triglycerides were associated with prostate cancer risk. Higher metabolic syndrome score (3-4 vs 0) was associated with a higher risk of fatal prostate cancer (HR 1.55; 95% CI: 0.89, 2.69; p trend = 0.08), although this finding was not statistically significant. Our findings suggest a positive association between midlife hypertension and diabetes and risk of total and aggressive prostate cancer. Further, metabolic syndrome as a combination of factors was associated with an increased risk of fatal prostate cancer.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Nyckelord
- Prostate cancer
- metabolic syndrome
- BMI
- hypertension
- triglycerides
- fasting blood glucose
- diabetes
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Dickerman, Barbr ...
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Torfadottir, Joh ...
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Valdimarsdottir, ...
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Wilson, Kathryn ...
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Steingrimsdottir ...
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Aspelund, Thor
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Batista, Julie L ...
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Fall, Katja, 197 ...
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Giovannucci, Edw ...
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Sigurdardottir, ...
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Tryggvadottir, L ...
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Gudnason, Vilmun ...
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Markt, Sarah C.
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Mucci, Lorelei A ...
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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Örebro universitet
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Karolinska Institutet