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Caloric restriction...
Caloric restriction ameliorates angiotensin II-induced mitochondrial remodeling and cardiac hypertrophy
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- Finckenberg, Piet (författare)
- Institute of Biomedicine, University of Helsinki, Helsinki, Finland
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- Eriksson, Ove (författare)
- Institute of Biomedicine, University of Helsinki, Helsinki, Finland
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- Baumann, Marc (författare)
- Institute of Biomedicine, University of Helsinki, Helsinki, Finland
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- Merasto, Saara (författare)
- Institute of Biomedicine, University of Helsinki, Helsinki, Finland
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- Lalowski, Maciej M. (författare)
- Institute of Biomedicine, University of Helsinki, Helsinki, Finland
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- Levijoki, Jouko (författare)
- Orion Pharma Ltd, Espoo, Finland
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- Haasio, Kristiina (författare)
- Orion Pharma Ltd, Espoo, Finland
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- Kytö, Ville (författare)
- Department of Medicine, Turku University Hospital, Turku, Finland
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- Muller, Dominik N. (författare)
- Experimental and Clinical Research Center, Max Delbrück Center, Berlin, Germany
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- Luft, Friedrich C. (författare)
- Experimental and Clinical Research Center, Max Delbrück Center, Berlin, Germany
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- Oresic, Matej, 1967- (författare)
- Örebro universitet,Institutionen för medicinska vetenskaper,VTT Technical Research Centre of Finland, Espoo, Finland
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- Mervaala, Eero (författare)
- Institute of Biomedicine, University of Helsinki, Helsinki, Finland
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(creator_code:org_t)
- Lippincott Williams & Wilkins, 2012
- 2012
- Engelska.
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Ingår i: Hypertension. - : Lippincott Williams & Wilkins. - 0194-911X .- 1524-4563. ; 59:1, s. 76-84
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Angiotensin II-induced cardiac damage is associated with oxidative stress-dependent mitochondrial dysfunction. Caloric restriction (CR), a dietary regimen that increases mitochondrial activity and cellular stress resistance, could provide protection. We tested that hypothesis in double transgenic rats harboring human renin and angiotensinogen genes (dTGRs). CR (60% of energy intake for 4 weeks) decreased mortality in dTGRs. CR ameliorated angiotensin II-induced cardiomyocyte hypertrophy, vascular inflammation, cardiac damage and fibrosis, cardiomyocyte apoptosis, and cardiac atrial natriuretic peptide mRNA overexpression. The effects were blood pressure independent and were linked to increased endoplasmic reticulum stress, autophagy, serum adiponectin level, and 5' AMP-activated protein kinase phosphorylation. CR decreased cardiac p38 phosphorylation, nitrotyrosine expression, and serum insulin-like growth factor 1 levels. Mitochondria from dTGR hearts showed clustered mitochondrial patterns, decreased numbers, and volume fractions but increased trans-sectional areas. All of these effects were reduced in CR dTGRs. Mitochondrial proteomic profiling identified 43 dTGR proteins and 42 Sprague-Dawley proteins, of which 29 proteins were in common in response to CR. We identified 7 proteins in CR dTGRs that were not found in control dTGRs. In contrast, 6 mitochondrial proteins were identified from dTGRs that were not detected in any other group. Gene ontology annotations with the Panther protein classification system revealed downregulation of cytoskeletal proteins and enzyme modulators and upregulation of oxidoreductase activity in dTGRs. CR provides powerful, blood pressure-independent, protection against angiotensin II-induced mitochondrial remodeling and cardiac hypertrophy. The findings support the notion of modulating cardiac bioenergetics to ameliorate angiotensin II-induced cardiovascular complications.
Ämnesord
- NATURVETENSKAP -- Biologi -- Biokemi och molekylärbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Biochemistry and Molecular Biology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Finckenberg, Pie ...
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Eriksson, Ove
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Baumann, Marc
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Merasto, Saara
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Lalowski, Maciej ...
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Levijoki, Jouko
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visa fler...
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Haasio, Kristiin ...
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Kytö, Ville
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Muller, Dominik ...
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Luft, Friedrich ...
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Oresic, Matej, 1 ...
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Mervaala, Eero
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visa färre...
- Om ämnet
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- NATURVETENSKAP
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NATURVETENSKAP
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och Biologi
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och Biokemi och mole ...
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Kardiologi
- Artiklar i publikationen
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Hypertension
- Av lärosätet
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Örebro universitet