Sökning: id:"swepub:oai:DiVA.org:oru-63661" >
Salinomycin inhibit...
Salinomycin inhibits prostate cancer growth and migration via induction of oxidative stress
-
- Ketola, Kirsi (författare)
- Medical Biotechnology, VTT Technical Research Centre of Finland, Espoo, Finland; University of Turku, Turku, Finland
-
- Hilvo, Mika (författare)
- VTT Technical Research Centre of Finland, Espoo, Finland
-
- Hyötyläinen, Tuulia, 1971- (författare)
- Örebro universitet,Institutionen för naturvetenskap och teknik,VTT Technical Research Centre of Finland, Espoo, Finland
-
visa fler...
-
- Vuoristo, Anu (författare)
- VTT Technical Research Centre of Finland, Espoo, Finland
-
- Ruskeepää, Anna Liisa (författare)
- VTT Technical Research Centre of Finland, Espoo, Finland
-
- Oresic, Matej, 1967- (författare)
- Örebro universitet,Institutionen för medicinska vetenskaper,VTT Technical Research Centre of Finland, Espoo, Finland
-
- Kallioniemi, Olli Pekka (författare)
- Medical Biotechnology, VTT Technical Research Centre of Finland, Espoo, Finland; University of Turku, Turku, Finland; Institute for Molecular Medicine, Finland (FIMM), University of Helsinki, Helsinki, Finland
-
- Iljin, Kristiina (författare)
- Medical Biotechnology, VTT Technical Research Centre of Finland, Espoo, Finland; University of Turku, Turku, Finland
-
visa färre...
-
(creator_code:org_t)
- 2012-01-03
- 2012
- Engelska.
-
Ingår i: British Journal of Cancer. - : Nature Publishing Group. - 0007-0920 .- 1532-1827. ; 106:1, s. 99-106
- Relaterad länk:
-
https://doi.org/10.1...
-
visa fler...
-
https://europepmc.or...
-
https://urn.kb.se/re...
-
https://doi.org/10.1...
-
visa färre...
Abstract
Ämnesord
Stäng
- BACKGROUND: We have shown that a sodium ionophore monensin inhibits prostate cancer cell growth. A structurally related compound to monensin, salinomycin, was recently identified as a putative cancer stem cell inhibitor.METHODS: The growth inhibitory potential of salinomycin was studied in a panel of prostate cells. To get insights into the mechanism of action, a variety of assays such as gene expression and steroid profiling were performed in salinomycin-exposed prostate cancer cells.RESULTS: Salinomycin inhibited the growth of prostate cancer cells, but did not affect non-malignant prostate epithelial cells. Salinomycin impacted on prostate cancer stem cell functions as evidenced by reduced aldehyde dehydrogenase activity and the fraction of CD44(+) cells. Moreover, salinomycin reduced the expression of MYC, AR and ERG, induced oxidative stress as well as inhibited nuclear factor-κB activity and cell migration. Furthermore, profiling steroid metabolites revealed increased levels of oxidative stress-inducing steroids 7-ketocholesterol and aldosterone and decreased levels of antioxidative steroids progesterone and pregnenolone in salinomycin-exposed prostate cancer cells.CONCLUSION: Our results indicate that salinomycin inhibits prostate cancer cell growth and migration by reducing the expression of key prostate cancer oncogenes, inducing oxidative stress, decreasing the antioxidative capacity and cancer stem cell fraction.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas