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Circulating triacyl...
Circulating triacylglycerol signatures in nonalcoholic fatty liver disease associated with the I148M variant in PNPLA3 and with obesity
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- Hyysalo, Jenni (författare)
- Department of Medicine, University of Helsinki, Helsinki, Finland; Minerva Foundation Institute for Medical Research, Helsinki, Finland
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- Gopalacharyulu, Peddinti (författare)
- VTT Technical Research Centre of Finland, Espoo, Finland
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- Bian, Hua (författare)
- Minerva Foundation Institute for Medical Research, Helsinki, Finland
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- Hyötyläinen, Tuulia, 1971- (författare)
- Örebro universitet,Institutionen för naturvetenskap och teknik,VTT Technical Research Centre of Finland, Espoo, Finland
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- Leivonen, Marja (författare)
- Department of Surgery, Helsinki University Central Hospital, Vantaa, Finland
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- Jaser, Nabil (författare)
- Department of Surgery, Helsinki University Central Hospital, Vantaa, Finland
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- Juuti, Anne (författare)
- Department of Surgery, Helsinki University Central Hospital, Vantaa, Finland
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- Honka, Miikka-Juhani (författare)
- Turku PET Centre, University of Turku, Turku, Finland
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- Nuutila, Pirjo (författare)
- Turku PET Centre, University of Turku, Turku, Finland
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- Olkkonen, Vesa M. (författare)
- Minerva Foundation Institute for Medical Research, Helsinki, Finland
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- Oresic, Matej, 1967- (författare)
- Örebro universitet,Institutionen för medicinska vetenskaper,VTT Technical Research Centre of Finland, Espoo, Finland
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- Yki-Järvinen, Hannele (författare)
- Department of Medicine, University of Helsinki, Helsinki, Finland; Minerva Foundation Institute for Medical Research, Helsinki, Finland
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(creator_code:org_t)
- 2013-12-13
- 2014
- Engelska.
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Ingår i: Diabetes. - : American Diabetes Association. - 0012-1797 .- 1939-327X. ; 63:1, s. 312-322
- Relaterad länk:
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https://diabetes.dia...
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https://urn.kb.se/re...
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https://doi.org/10.2...
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Abstract
Ämnesord
Stäng
- We examined whether relative concentrations of circulating triacylglycerols (TAGs) between carriers compared with noncarriers of PNPLA3(I148M) gene variant display deficiency of TAGs, which accumulate in the liver because of defective lipase activity. We also analyzed the effects of obesity-associated nonalcoholic fatty liver disease (NAFLD) independent of genotype, and of NAFLD due to either PNPLA3(I148M) gene variant or obesity on circulating TAGs. A total of 372 subjects were divided into groups based on PNPLA3 genotype or obesity. Absolute and relative deficiency of distinct circulating TAGs was observed in the PNPLA3(148MM/148MI) compared with the PNPLA3(148II) group. Obese and 'nonobese' groups had similar PNPLA3 genotypes, but the obese subjects were insulin-resistant. Liver fat was similarly increased in obese and PNPLA3(148MM/148MI) groups. Relative concentrations of TAGs in the obese subjects versus nonobese displayed multiple changes. These closely resembled those between obese subjects with NAFLD but without PNPLA3(I148M) versus those with the I148M variant and NAFLD. The etiology of NAFLD influences circulating TAG profiles. 'PNPLA3 NAFLD' is associated with a relative deficiency of TAGs, supporting the idea that the I148M variant impedes intrahepatocellular lipolysis rather than stimulates TAG synthesis. 'Obese NAFLD' is associated with multiple changes in TAGs, which can be attributed to obesity/insulin resistance rather than increased liver fat content per se.
Ämnesord
- NATURVETENSKAP -- Kemi -- Analytisk kemi (hsv//swe)
- NATURAL SCIENCES -- Chemical Sciences -- Analytical Chemistry (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
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Diabetes
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- Av författaren/redakt...
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Hyysalo, Jenni
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Gopalacharyulu, ...
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Bian, Hua
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Hyötyläinen, Tuu ...
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Leivonen, Marja
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Jaser, Nabil
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Juuti, Anne
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Honka, Miikka-Ju ...
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Nuutila, Pirjo
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Olkkonen, Vesa M ...
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Oresic, Matej, 1 ...
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Yki-Järvinen, Ha ...
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- Om ämnet
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- NATURVETENSKAP
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NATURVETENSKAP
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och Kemi
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och Analytisk kemi
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Endokrinologi oc ...
- Artiklar i publikationen
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Diabetes
- Av lärosätet
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Örebro universitet