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Food deprivation in...
Food deprivation increases bacterial translocation after non-lethal haemorrhage in rats
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- Bark, Tor (författare)
- Karolinska Institutet
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- Katouli, Mohammad (författare)
- Department of Surgery, Karolinska Hospital, Stockholm, Sweden
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- Svenberg, Torgny E. (författare)
- Department of Surgery, Karolinska Hospital, Stockholm, Sweden
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- Ljungqvist, Olle, 1954- (författare)
- Karolinska Institutet,Örebro universitet,Institutionen för medicinska vetenskaper,Department of Surgery, Karolinska Hospital, Stockholm, Sweden
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(creator_code:org_t)
- Taylor & Francis Scandinavia, 1995
- 1995
- Engelska.
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Ingår i: European Journal of Surgery. - : Taylor & Francis Scandinavia. - 1102-4151 .- 1741-9271. ; 161:2, s. 67-71
- Relaterad länk:
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Abstract
Ämnesord
Stäng
- OBJECTIVE:To investigate whether brief fasting before the induction of hypotension by non-lethal haemorrhage may induce translocation of enteric bacteria to mesenteric lymph nodes or blood in rats.DESIGN:Laboratory experiment.SETTING:University departments of surgery and microbiology, Sweden.MATERIAL:39 Male Sprague-Dawley rats.INTERVENTIONS:20 animals were fasted for 24 hours, all 39 then underwent controlled haemorrhage for 60 minutes that reduced the blood pressure to 55 mm Hg.MAIN OUTCOME MEASURES:Differences in blood loss, blood glucose concentrations, and packed cell volume; and aerobic cultures of mesenteric lymph nodes and blood.RESULTS:Fasted rats (n = 20) lost 2.3% of blood volume compared with 2.8% in fed rats(p < 0.001). Packed cell volume dropped by 11.3% in fasted rats and 16.5% in fed rats (p < 0.001). Glucose concentrations rose by 7.0 mmol/l in fasted rats compared with 21.0 mmol/l in fed rats (p < 0.001). Mesenteric lymph nodes contained enteric bacteria in 14/20 fasted rats compared with 6/19 fed rats (p < 0.05). In 4 fasted rats blood cultures grew pathogenic bacteria compared with no fed rats (p = 0.11). The number of bacteria found in mesenteric lymph nodes was significantly greater in fasted than in fed rats (p = 0.01).CONCLUSIONS:Brief fasting before hypotension caused by non-lethal haemorrhage was associated with significantly increased bacterial translocation compared with fed animals. Increases in blood glucose concentrations and plasma refill may have had a protective effect in fed rats. These experiments may be of clinical relevance as elective operations are usually preceded by overnight fasting.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Fysiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Physiology (hsv//eng)
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- ref (ämneskategori)
- art (ämneskategori)
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