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High cyclin A expre...
High cyclin A expression, but not Ki67, is associated with early recurrence in desmoid tumors
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- Santti, Kirsi (författare)
- Comprehensive Cancer Center, Helsinki University Hospital and University of Helsinki, Helsinki, Finland
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- Ihalainen, Hanna (författare)
- Comprehensive Cancer Center, Helsinki University Hospital and University of Helsinki, Helsinki, Finland; Department of Plastic Surgery, Helsinki University Hospital and University of Helsinki, Helsinki, Finland
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- Rönty, Mikko (författare)
- Department of Pathology, HUSLAB and University of Helsinki, Helsinki, Finland
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- Böhling, Tom (författare)
- Department of Pathology, HUSLAB and University of Helsinki, Helsinki, Finland
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- Karlsson, Christina, 1968- (författare)
- Örebro universitet,Institutionen för hälsovetenskaper,Department of Medical Diagnostics
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- Haglund, Caj (författare)
- Department of Surgery, Helsinki University Hospital and University of Helsinki, Helsinki, Finland; Reseach Program Unit, Translational Cancer Biology, University of Helsinki, Helsinki, Finland
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- Tarkkanen, Maija (författare)
- Comprehensive Cancer Center, Helsinki University Hospital and University of Helsinki, Helsinki, Finland
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- Blomqvist, Carl (författare)
- Comprehensive Cancer Center, Helsinki University Hospital and University of Helsinki, Helsinki, Finland; Department of Oncology, Örebro University Hospital, Örebro, Sweden
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(creator_code:org_t)
- 2018-06-07
- 2018
- Engelska.
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Ingår i: Journal of Surgical Oncology. - : Wiley-Interscience Publishers. - 0022-4790 .- 1096-9098. ; 118:1, s. 192-198
- Relaterad länk:
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https://helda.helsin...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- BACKGROUND AND OBJECTIVES: Desmoid tumors are soft-tissue tumors originating from myofibroblasts with a tendency to recur after surgery. High expression of proliferation markers is associated with shortened progression-free and/or overall survival in many neoplasms, including soft-tissue sarcomas. We investigated the prognostic role of cyclin A and Ki67 in desmoid tumors by immunohistochemistry.METHODS: The study included 76 patients with desmoid tumor operated at Helsinki University Hospital between 1987 and 2011. A tissue micro array (TMA) was constructed and the TMA sections were immunostained with cyclin A and Ki67 antibodies. A computer-assisted image analysis was performed.RESULTS: Cyclin A expression was evaluable in 74 and Ki67 in 70 patients. Cyclin A immunopositivity varied from 0% to 9.9%, with a mean of 1.9%. Cyclin A expression correlated significantly with Ki67. Cyclin A expression was associated with recurrence-free survival (HR 1.9, 95% CI = 1.1-3.2, P = .02), as were positive margin (HR 6.0, 95% CI = 1.6-22.5, P = .008) and extremity location (HR 5.3, 95% CI = 1.7-16.8, P = 0.005). Ki67 immunopositivity varied from 0.33% to 13.8%, with a mean of 4.6%, but had no significant prognostic impact (HR 1.1, P = .2).CONCLUSIONS: Our study indicates that cyclin A may be a new prognostic biomarker in surgically treated desmoid tumors.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kirurgi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Surgery (hsv//eng)
Nyckelord
- Aggressive fibromatosis
- biomarkers
- cyclins
- immunohistochemistry
- prognostic factors
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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