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Discovery of mcr-1-...
Discovery of mcr-1-Mediated Colistin Resistance in a Highly Virulent Escherichia coli Lineage
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- Forde, Brian M. (författare)
- The University of Queensland, Brisbane, Queensland, Australia
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- Zowawi, Hosam M. (författare)
- Australian Infectious Diseases Research Centre, The University of Queensland, Brisbane, Queensland, Australia; The University of Queensland, UQ Centre for Clinical Research (UQCCR), Herston, Queensland, Australia; College of Medicine, King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia; World Health Organization Collaborating Centre for Infection Prevention and Control, Riyadh, Saudi Arabia; Gulf Cooperation Council Center for Infection Control, Riyadh, Saudi Arabia; King Abdullah International Medical Research Centre, Riyadh, Saudi Arabia
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- Harris, Patrick N. A. (författare)
- The University of Queensland, UQ Centre for Clinical Research (UQCCR), Herston, Queensland, Australia; Pathology Queensland, Brisbane, Queensland, Australia
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- Roberts, Leah (författare)
- The University of Queensland, Brisbane, Queensland, Australia
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- Ibrahim, Emad (författare)
- Microbiology Division, Department of Laboratory Medicine and Pathology, Hamad Medical Corporation, Doha, Qatar
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- Shaikh, Nissar (författare)
- Department of Neurosurgery, Hamad Medical Corporation, Weill Cornell Medical College in Qatar, Ar-Rayyan, Qatar
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- Deshmukh, Anand (författare)
- Microbiology Division, Department of Laboratory Medicine and Pathology, Hamad Medical Corporation, Doha, Qatar
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- Sid Ahmed, Mazen, 1970- (författare)
- Örebro universitet,Institutionen för naturvetenskap och teknik,Microbiology Division, Department of Laboratory Medicine and Pathology, Hamad Medical Corporation, Doha, Qatar,The Life Science Centre, Biology
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- Al Maslamani, Muna (författare)
- Department of Infectious Diseases, Hamad General Hospital, Doha, Qatar
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- Cottrell, Kyra (författare)
- The University of Queensland, UQ Centre for Clinical Research (UQCCR), Herston, Queensland, Australia
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- Trembizki, Ella (författare)
- The University of Queensland, UQ Centre for Clinical Research (UQCCR), Herston, Queensland, Australia
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- Sundac, Lana (författare)
- The University of Queensland, UQ Centre for Clinical Research (UQCCR), Herston, Queensland, Australia; Pathology Queensland, Brisbane, Queensland, Australia
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- Yu, Heidi H. (författare)
- Monash Biomedicine Discovery Institute, Department of Microbiology, Monash University, Victoria, Australia
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- Li, Jian (författare)
- Monash Biomedicine Discovery Institute, Department of Microbiology, Monash University, Victoria, Australia
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- Schembri, Mark A. (författare)
- The University of Queensland, Brisbane, Queensland, Australia
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- Whiley, David M. (författare)
- The University of Queensland, UQ Centre for Clinical Research (UQCCR), Herston, Queensland, Australia; Pathology Queensland, Brisbane, Queensland, Australia
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- Paterson, David L. (författare)
- The University of Queensland, UQ Centre for Clinical Research (UQCCR), Herston, Queensland, Australia
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- Beatson, Scott A. (författare)
- The University of Queensland, Brisbane, Queensland, Australia
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(creator_code:org_t)
- American Society for Microbiology, 2018
- 2018
- Engelska.
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Ingår i: mSphere. - : American Society for Microbiology. - 2379-5042. ; 3:5
- Relaterad länk:
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https://doi.org/10.1...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Resistance to last-line polymyxins mediated by the plasmid-borne mobile colistin resistance gene (mcr-1) represents a new threat to global human health. Here we present the complete genome sequence of an mcr-1-positive multidrug-resistant Escherichia coli strain (MS8345). We show that MS8345 belongs to serotype O2:K1:H4, has a large 241,164-bp IncHI2 plasmid that carries 15 other antibiotic resistance genes (including the extended-spectrum β-lactamase blaCTX-M-1) and 3 putative multidrug efflux systems, and contains 14 chromosomally encoded antibiotic resistance genes. MS8345 also carries a large ColV-like virulence plasmid that has been associated with E. coli bacteremia. Whole-genome phylogeny revealed that MS8345 clusters within a discrete clade in the sequence type 95 (ST95) lineage, and MS8345 is very closely related to the highly virulent O45:K1:H4 clone associated with neonatal meningitis. Overall, the acquisition of a plasmid carrying resistance to colistin and multiple other antibiotics in this virulent E. coli lineage is concerning and might herald an era where the empirical treatment of ST95 infections becomes increasingly more difficult.Importance: Escherichia coli ST95 is a globally disseminated clone frequently associated with bloodstream infections and neonatal meningitis. However, the ST95 lineage is defined by low levels of drug resistance amongst clinical isolates, which normally provides for uncomplicated treatment options. Here, we provide the first detailed genomic analysis of an E. coli ST95 isolate that has both high virulence potential and resistance to multiple antibiotics. Using the genome, we predicted its virulence and antibiotic resistance mechanisms, which include resistance to last-line antibiotics mediated by the plasmid-borne mcr-1 gene. Finding an ST95 isolate resistant to nearly all antibiotics that also has a high virulence potential is of major clinical importance and underscores the need to monitor new and emerging trends in antibiotic resistance development in this important global lineage.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Mikrobiologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Microbiology in the medical area (hsv//eng)
- NATURVETENSKAP -- Biologi -- Genetik (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Genetics (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Infektionsmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Infectious Medicine (hsv//eng)
Nyckelord
- Escherichia coli
- antibiotic resistance
- genome analysis
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Forde, Brian M.
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Zowawi, Hosam M.
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Harris, Patrick ...
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Roberts, Leah
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Ibrahim, Emad
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Shaikh, Nissar
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Deshmukh, Anand
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Sid Ahmed, Mazen ...
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Al Maslamani, Mu ...
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Cottrell, Kyra
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Trembizki, Ella
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Sundac, Lana
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Yu, Heidi H.
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Li, Jian
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Schembri, Mark A ...
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Whiley, David M.
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Paterson, David ...
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Beatson, Scott A ...
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