Sökning: id:"swepub:oai:DiVA.org:oru-70126" >
No evidence of Chla...
No evidence of Chlamydia pneumoniae in the synovia of patients with osteoarthritis
-
- Edvinsson, Marie (författare)
- Uppsala universitet,Infektionssjukdomar
-
- Welvaart, Nicole, 1972- (författare)
- Örebro universitet,Institutionen för medicinska vetenskaper,Department of Orthopaedics,Örebro Univ, Sch Med Sci, Dept Orthopaed, Örebro, Sweden
-
- Ryttberg, Lars (författare)
- Department of Orthopaedics, School of Medical Sciences, Örebro University, Örebro, Sweden,Örebro Univ, Sch Med Sci, Dept Orthopaed, Örebro, Sweden
-
visa fler...
-
- Wretenberg, Per, 1963- (författare)
- Örebro universitet,Institutionen för medicinska vetenskaper,Department of Orthopaedics,Örebro Univ, Sch Med Sci, Dept Orthopaed, Örebro, Sweden
-
- Vikerfors, Tomas (författare)
- Department of Infectious Diseases, Örebro University, Örebro, Sweden; Västerås Central Hospital, Västerås, Sweden,Örebro Univ, Dept Infect Dis, Örebro, Sweden; Västerås Hosp, Västerås, Sweden
-
- Nyström-Rosander, Christina (författare)
- Uppsala universitet,Infektionssjukdomar
-
visa färre...
-
(creator_code:org_t)
- 2018-11-05
- 2019
- Engelska.
-
Ingår i: Journal of international medical research. - : Sage Publications. - 0300-0605 .- 1473-2300. ; 47:2, s. 635-640
- Relaterad länk:
-
https://doi.org/10.1...
-
visa fler...
-
https://journals.sag...
-
https://uu.diva-port... (primary) (Raw object)
-
https://urn.kb.se/re...
-
https://doi.org/10.1...
-
https://urn.kb.se/re...
-
visa färre...
Abstract
Ämnesord
Stäng
- OBJECTIVE: Osteoarthritis (OA) is a common cause of disability affecting millions of people of all ages worldwide. The pathogenesis involves an inflammatory component, but the cause of the inflammation remains incompletely understood. The intracellular bacteria Chlamydia trachomatis and C. pneumoniae have been demonstrated in patients with reactive arthritis. Both of these microorganisms can cause chronic and persistent infections, with C. trachomatis being the most common cause of reactive arthritis. This study was performed to investigate the presence of C. pneumoniae in a large number of patients with primary OA.METHODS: The study included 75 patients who underwent total knee arthroplasty. During surgery, a synovial biopsy was performed and synovial fluid drawn. Real-time polymerase chain reaction (PCR) of C. pneumoniae was run on all patients, and real-time PCR of bacterial 16S rDNA was conducted on 30 of the 75 patients to screen for the presence of other bacteria.RESULTS: Real-time PCR showed no evidence of the presence of C. pneumoniae in the patients' specimens, nor were other bacteria detected.CONCLUSIONS: Although an inflammatory component is part of the pathogenesis of OA, we found no evidence indicating that C. pneumoniae is a stimulator of that inflammation.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Infektionsmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Infectious Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reumatologi och inflammation (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Rheumatology and Autoimmunity (hsv//eng)
Nyckelord
- Chlamydia pneumoniae
- Osteoarthritis
- inflammation
- knee arthroplasty
- polymerase chain reaction
- synovial membrane
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas