Sökning: id:"swepub:oai:DiVA.org:oru-72243" >
Impaired incretin r...
Impaired incretin response after a mixed meal is associated with insulin resistance in nondiabetic men
-
- Rask, Eva, 1958- (författare)
- Dept. of Pub. Hlth. and Clin. Med., Umeå University Hospital, Umeå, Sweden
-
- Olsson, Tommy (författare)
- Umeå universitet,Medicin
-
- Söderberg, Stefan (författare)
- Umeå universitet,Kardiologi
-
visa fler...
-
- Johnson, Owe (författare)
- Umeå universitet,Kardiologi
-
- Seckl, J. (författare)
- Molecular Endocrinology Laboratory, University of Edinburgh, Western General Hospital, Edinburgh, United Kingdom
-
- Holst, J. J. (författare)
- Department of Medical Physiology, Panum Institute, University of Copenhagen, Copenhagen, Denmark
-
- Ahrén, B. (författare)
- Department of Medicine, Lund University, Lund, Sweden
-
visa färre...
-
Dept of Pub. Hlth. and Clin. Med., Umeå University Hospital, Umeå, Sweden Medicin (creator_code:org_t)
- American Diabetes Association, 2001
- 2001
- Engelska.
-
Ingår i: Diabetes Care. - : American Diabetes Association. - 0149-5992 .- 1935-5548. ; 24:9, s. 1640-1645
- Relaterad länk:
-
http://care.diabetes...
-
visa fler...
-
https://urn.kb.se/re...
-
https://doi.org/10.2...
-
https://urn.kb.se/re...
-
visa färre...
Abstract
Ämnesord
Stäng
- OBJECTIVE:To investigate whether features of the insulin resistance syndrome are associated with altered incretin responses to food intake.RESEARCH DESIGN AND METHODS:From a population-based study, 35 men were recruited, representing a wide spectrum of insulin sensitivity and body weight. Each subject underwent a hyperinsulinemic-euglycemic clamp to determine insulin sensitivity. A mixed meal was given, and plasma levels of gastric inhibitory polypeptide (GIP) and glucagon-like peptide 1 (GLP-1), as well as insulin, glucagon, and glucose were measured.RESULTS:Insulin resistance was associated with impaired GIP and GLP-1 responses to a mixed meal. The total area under the curve (AUC) of the GIP response after the mixed meal was associated with insulin sensitivity (r = 0.54, P < 0.01). There was a significant difference between the highest and the lowest tertile of insulin sensitivity (P < 0.05). GLP-1 levels 15 min after food intake were significantly lower in the most insulin-resistant tertile compared with the most insulin-sensitive tertile. During the first hour, the AUC of GLP-1 correlated significantly with insulin sensitivity (r = 0.47, P < 0.01). Multiple linear regression analysis showed that insulin resistance, but not obesity, was an independent predictor of these decreased incretin responses.CONCLUSIONS:In insulin resistance, the GIP and GLP-1 responses to a mixed meal are impaired and are related to the degree of insulin resistance. Decreased incretin responsiveness may be of importance for the development of impaired glucose tolerance.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas