Sex Differences in Comorbidity Patterns of Attention-Deficit/Hyperactivity Disorder

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Sex Differences in Comorbidity Patterns of Attention-Deficit/Hyperactivity Disorder

Ottosen, Cæcilie (author): National Centre for Register-based Research, School of Business and Social Sciences, Aarhus University, Aarhus, Denmark; The Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, Aarhus, Denmark; Centre for Integrated Register-based Research at Aarhus University (CIRRAU), Aarhus, Denmark

Larsen, Janne Tidselbak (author): National Centre for Register-based Research, School of Business and Social Sciences, Aarhus University, Aarhus, Denmark; The Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, Aarhus, Denmark; Centre for Integrated Register-based Research at Aarhus University (CIRRAU), Aarhus, Denmark

Faraone, Stephen V (author): SUNY Upstate Medical University, Syracuse, NY, and the K.G. Jebsen Centre for Research on Neuropsychiatric Disorders, University of Bergen, Norway

Chen, Qi (author): Karolinska Institutet

Hartman, Catharina (author): University of Groningen, The Netherlands

Larsson, Henrik, 1975- (author): Örebro universitet,Institutionen för medicinska vetenskaper,Karolinska Institutet, Stockholm, Sweden

Petersen, Liselotte (author): National Centre for Register-based Research, School of Business and Social Sciences, Aarhus University, Aarhus, Denmark; The Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, Aarhus, Denmark; Centre for Integrated Register-based Research at Aarhus University (CIRRAU), Aarhus, Denmark

Dalsgaard, Søren (author): National Centre for Register-based Research, School of Business and Social Sciences, Aarhus University, Aarhus, Denmark; The Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, Aarhus, Denmark; Hospital of Telemark, Kragerø, Norway

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National Centre for Register-based Research, School of Business and Social Sciences, Aarhus University, Aarhus, Denmark; The Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, Aarhus, Denmark; Centre for Integrated Register-based Research at Aarhus University (CIRRAU), Aarhus, Denmark SUNY Upstate Medical University, Syracuse, NY, and the KG. Jebsen Centre for Research on Neuropsychiatric Disorders, University of Bergen, Norway (creator_code:org_t)

Elsevier, 2019
2019
English.
In: Journal of the American Academy of Child and Adolescent Psychiatry. - : Elsevier. - 0890-8567 .- 1527-5418. ; 58:4, s. 412-422.e3

Related links:: https://urn.kb.se/re...; show more...; https://doi.org/10.1...; http://kipublication...; show less...

Journal article (peer-reviewed)

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OBJECTIVE: To investigate sex differences in associations between attention-deficit/hyperactivity disorder (ADHD) and a spectrum of comorbid disorders.METHOD: The study population included all children born in Denmark from 1981 through 2013 (N = 1,665,729). Data were merged from Danish registers and information was obtained on birth characteristics, socioeconomic status, familial psychiatric history, and diagnoses of ADHD (n = 32,308) and comorbid disorders. To estimate absolute and relative risks of comorbid disorders, incidence rates and adjusted hazard ratios (HRs) with 95% CIs were calculated for female and male individuals. In addition, interactions between ADHD and sex in association with comorbid disorders were estimated as HR ratios (HRRs) in female and male individuals (95% CIs).RESULTS: Individuals diagnosed with ADHD had significantly increased absolute and relative risks of all 12 comorbid psychiatric disorders investigated. ADHD-sex interactions were found for some comorbid disorders. Compared with male individuals, ADHD in female individuals showed a stronger association with autism spectrum disorder (HRR 1.86, 95% CI 1.62-2.14), oppositional defiant/conduct disorder (HRR 1.97, 95% CI 1.68-2.30), intellectual disability (HRR 1.79, 95% CI 1.54-2.09), personality disorders (HRR 1.23, 95% CI 1.06-1.43), schizophrenia (HRR 1.21, 95% CI 1.02-1.43), substance use disorders (HRR 1.21, 95% CI 1.07-1.38), and suicidal behavior (1.28, 95% CI 1.12-1.47). The remaining disorders showed no significant sex differences in association with ADHD.CONCLUSION: This study indicates that the association between ADHD and several comorbid disorders is stronger in female than in male individuals. These important findings add to the literature on sex differences in ADHD and suggest that female individuals diagnosed with ADHD are a more vulnerable group of patients.

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By the author/editor: Ottosen, Cæcilie; Larsen, Janne Ti ...; Faraone, Stephen ...; Chen, Qi; Hartman, Cathari ...; Larsson, Henrik, ...; show more...; Petersen, Liselo ...; Dalsgaard, Søren; show less...

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MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Psychiatry

Articles in the publication: Journal of the A ...

By the university: Örebro University; Karolinska Institutet

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Sex Differences in Comorbidity Patterns of Attention-Deficit/Hyperactivity Disorder

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