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Association Between Later Life Lifestyle Factors and Alzheimer's Disease Biomarkers in Non-Demented Individuals : A Longitudinal Descriptive Cohort Study

Reijs, Babette L R (författare)
Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Alzheimer Center Limburg, Maastricht University, Maastricht, The Netherlands
Vos, Stephanie J B (författare)
Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Alzheimer Center Limburg, Maastricht University, Maastricht, The Netherlands
Soininen, Hilkka (författare)
Institute of Clinical Medicine, Neurology, University of Eastern Finland, Kuopio, Finland; Department of Neurology, Kuopio University Hospital, Kuopio, Finland
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Lötjonen, Jyrki (författare)
VTT Technical Research Centre of Finland, Tampere, Finland; Combinostics Oy, Tampere, Finland,VTT Technical Research Center of Finland, Espoo
Koikkalainen, Juha (författare)
VTT Technical Research Centre of Finland, Tampere, Finland; Combinostics Oy, Tampere, Finland,VTT Technical Research Center of Finland, Espoo
Pikkarainen, Maria (författare)
Institute of Clinical Medicine, Neurology, University of Eastern Finland, Kuopio, Finland
Hall, Anette (författare)
Institute of Clinical Medicine, Neurology, University of Eastern Finland, Kuopio, Finland
Vanninen, Ritva (författare)
Department of Radiology, Kuopio University Hospital, Kuopio, Finland
Liu, Yawu (författare)
Institute of Clinical Medicine, Neurology, University of Eastern Finland, Kuopio, Finland; Department of Radiology, Kuopio University Hospital, Kuopio, Finland
Herukka, Sanna-Kaisa (författare)
Institute of Clinical Medicine, Neurology, University of Eastern Finland, Kuopio, Finland; Department of Neurology, Kuopio University Hospital, Kuopio, Finland
Freund-Levi, Yvonne (författare)
Örebro universitet,Institutionen för medicinska vetenskaper,Department of NVS, Section of Clinical Geriatrics, Karolinska Institutet, Karolinska University Hospital, Huddinge, Sweden
Frisoni, Giovanni B (författare)
LENITEM, IRCCS Fatebenefratelli, Brescia,Centro San Giovanni di Dio Fatebenefratelli
Frölich, Lutz (författare)
Department of Geriatric Psychiatry, Medical Faculty Mannheim, University of Heidelberg, Germany
Nobili, Flavio (författare)
Department of Neuroscience (DINOGMI), Clinical Neurology, University of Genoa and IRCCS AOU San Martino-IST Genoa, Italy,Ospedale Policlinico San Martino
Rikkert, Marcel Olde (författare)
Department of Geriatrics, Radboud University Medical Centre, Nijmegen, The Netherlands
Spiru, Luiza (författare)
Carol Davila’ University of Medicine and Pharmacy, Bucharest, Romania
Tsolaki, Magda (författare)
Aristotle University of Thessaloniki, Memory and Dementia Centre, G. Papanicolaore General Hospital, Thessaloniki, Greece
Wallin, Åsa K. (författare)
Lund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups
Scheltens, Philip (författare)
Department of Neurology and Alzheimer Center, VU University Medical Center, Amsterdam, The Netherlands,Amsterdam UMC - Vrije Universiteit Amsterdam
Verhey, Frans (författare)
Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Alzheimer Center Limburg, Maastricht University, Maastricht, The Netherlands
Visser, Pieter Jelle (författare)
Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Alzheimer Center Limburg, Maastricht University, Maastricht, The Netherlands; Department of Neurology and Alzheimer Center, VU University Medical Center, Amsterdam, The Netherlands,Amsterdam UMC - Vrije Universiteit Amsterdam
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 (creator_code:org_t)
IOS Press, 2017
2017
Engelska.
Ingår i: Journal of Alzheimer's Disease. - : IOS Press. - 1387-2877 .- 1875-8908. ; 60:4, s. 1387-1395
Relaterad länk:
http://dx.doi.org/10...
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https://urn.kb.se/re...
https://doi.org/10.3...
http://kipublication...
https://lup.lub.lu.s...
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  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
Stäng  
  • BACKGROUND: Lifestyle factors have been associated with the risk of dementia, but the association with Alzheimer's disease (AD) remains unclear.OBJECTIVE: To examine the association between later life lifestyle factors and AD biomarkers (i.e., amyloid-β 1-42 (Aβ42) and tau in cerebrospinal fluid (CSF), and hippocampal volume) in individuals with subjective cognitive decline (SCD) and mild cognitive impairment (MCI). In addition, to examine the effect of later life lifestyle factors on developing AD-type dementia in individuals with MCI.METHODS: We selected individuals with SCD (n = 111) and MCI (n = 353) from the DESCRIPA and Kuopio Longitudinal MCI studies. CSF Aβ42 and tau concentrations were assessed with ELISA assay and hippocampal volume with multi-atlas segmentation. Lifestyle was assessed by clinical interview at baseline for: social activity, physical activity, cognitive activity, smoking, alcohol consumption, and sleep. We performed logistic and Cox regression analyses adjusted for study site, age, gender, education, and diagnosis. Prediction for AD-type dementia was performed in individuals with MCI only.RESULTS: Later life lifestyle factors were not associated with AD biomarkers or with conversion to AD-type dementia. AD biomarkers were strongly associated with conversion to AD-type dementia, but these relations were not modulated by lifestyle factors. Apolipoprotein E (APOE) genotype did not influence the results.CONCLUSIONS: Later life lifestyle factors had no impact on key AD biomarkers in individuals with SCD and MCI or on conversion to AD-type dementia in MCI.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Neurologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Neurology (hsv//eng)

Nyckelord

Alcohol consumption
Alzheimer’s disease
amyloid-β (1–42)
cerebrospinal fluid
cognitive reserve
exercise
hippocampus
lifestyle
mild cognitive impairment
Alcohol consumption
Alzheimer's disease
amyloid-β (1-42)
cerebrospinal fluid
cognitive reserve
exercise
hippocampus
lifestyle
mild cognitive impairment

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