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Inflammatory and coagulatory markers and exposure to different size fractions of particle mass, number and surface area air concentrations in Swedish iron foundries, in particular respirable quartz

Westberg, Håkan, 1949- (författare)
Örebro universitet,Institutionen för naturvetenskap och teknik,Department of Occupational and Environmental Medicine Örebro University Hospital, Örebro, Sweden,Inflammatory Response and Infection Susceptibility Centre (iRiSC)
Hedbrant, Alexander, 1987- (författare)
Örebro universitet,Institutionen för medicinska vetenskaper,Inflammatory Response and Infection Susceptibility Centre (iRiSC)
Persson, Alexander, 1978- (författare)
Örebro universitet,Institutionen för medicinska vetenskaper,Inflammatory Response and Infection Susceptibility Centre (iRiSC)
visa fler...
Bryngelsson, Ing-Liss (författare)
Department of Occupational and Environmental Medicine, Faculty of Medicine and Health, Örebro University, Sweden
Johansson, Anders (författare)
Department of Occupational and Environmental Medicine, Faculty of Medicine and Health, Örebro University, Sweden
Ericsson, Annette, 1963- (författare)
Örebro universitet,Institutionen för hälsovetenskaper,Department of Occupational and Environmental Medicine
Sjögren, Bengt (författare)
Karolinska Institutet
Stockfelt, Leo, 1981 (författare)
Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för samhällsmedicin och folkhälsa,Institute of Medicine, School of Public Health and Community Medicine
Särndahl, Eva, 1963- (författare)
Örebro universitet,Institutionen för medicinska vetenskaper,Inflammatory Response and Infection Susceptibility Centre (iRiSC)
Andersson, Lena, 1965- (författare)
Örebro universitet,Institutionen för medicinska vetenskaper,Region Örebro län,Department of Occupational and Environmental Medicine
visa färre...
 (creator_code:org_t)
2019-06-04
2019
Engelska.
Ingår i: International Archives of Occupational and Environmental Health. - : Springer Berlin/Heidelberg. - 0340-0131 .- 1432-1246. ; 92:8, s. 1087-1098
  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
Stäng  
  • PURPOSE: To study the relationship between inhalation of airborne particles and quartz in Swedish iron foundries and markers of inflammation and coagulation in blood.METHODS: Personal sampling of respirable dust and quartz was performed for 85 subjects in three Swedish iron foundries. Stationary measurements were used to study the concentrations of respirable dust and quartz, inhalable and total dust, PM10 and PM2.5, as well as the particle surface area and the particle number concentrations. Markers of inflammation, namely interleukins (IL-1β, IL-6, IL-8, IL-10 and IL-12), C-reactive protein, and serum amyloid A (SAA) were measured in plasma or serum, together with markers of coagulation including fibrinogen, factor VIII (FVIII), von Willebrand factor and D-dimer. Complete sampling was performed on the second or third day of a working week after a work-free weekend, and follow-up samples were collected 2 days later. A mixed model analysis was performed including sex, age, smoking, infections, blood group, sampling day and BMI as covariates.RESULTS: The average 8-h time-weighted average air concentrations of respirable dust and quartz were 0.85 mg/m3 and 0.052 mg/m3, respectively. Participants in high-exposure groups with respect to some of the measured particle types exhibited significantly elevated levels of SAA, fibrinogen and FVIII.CONCLUSIONS: These observed relationships between particle exposure and inflammatory markers may indicate an increased risk of cardiovascular disease among foundry workers with high particulate exposure.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Hälsovetenskap -- Arbetsmedicin och miljömedicin (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Health Sciences -- Occupational Health and Environmental Health (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Lungmedicin och allergi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Respiratory Medicine and Allergy (hsv//eng)

Nyckelord

Inflammatory markers
Iron foundries
Particle mass
Particle number
Particle surface area
Respirable quartz
Occupational and Environmental Medicine
Arbets- och miljömedicin
Biomedicin
Biomedicine
Inflammatory markers
Iron foundries
Particle mass
Particle number
Particle surface area
Respirable quartz

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