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Evaluation of in vi...
Evaluation of in vitro activity of ceftazidime/avibactam and ceftolozane/tazobactam against MDR Pseudomonas aeruginosa isolates from Qatar
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- Sid Ahmed, Mazen, 1970- (författare)
- Örebro universitet,Institutionen för naturvetenskap och teknik,Microbiology Division, Hamad Medical Corporation, Doha, Qatar,The Life Science Centre
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- Abdel Hadi, Hamad (författare)
- Communicable Diseases Center, Hamad Medical Corporation, Doha, Qatar
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- Hassan, Abubaker A. I. (författare)
- Division of General Medicine, Wayne State University, Detroit, MI, USA
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- Abu Jarir, Sulieman (författare)
- Communicable Diseases Center, Hamad Medical Corporation, Doha, Qatar
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- Al-Maslamani, Muna A. (författare)
- Communicable Diseases Center, Hamad Medical Corporation, Doha, Qatar
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- Eltai, Nahla Omer (författare)
- Biomedical Research Center, Qatar University, Doha, Qatar
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- Dousa, Khalid M. (författare)
- University Hospitals Cleveland Medical Center, Cleveland, OH, USA
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- Hujer, Andrea M. (författare)
- Department of Medicine, Case Western Reserve University School of Medicine, Cleveland, OH, USA; Louis Stokes Cleveland, Department of Veterans Affairs Medical Center, Cleveland, OH, USA
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- Sultan, Ali A. (författare)
- Department of Microbiology and Immunology, Weill Cornell Medicine-Qatar, Doha, Qatar
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- Söderquist, Bo, 1955- (författare)
- Örebro universitet,Institutionen för medicinska vetenskaper,The Life Science Centre
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- Bonomo, Robert A. (författare)
- Department of Medicine, Case Western Reserve University School of Medicine, Cleveland, OH, USA; Louis Stokes Cleveland, Department of Veterans Affairs Medical Center, Cleveland, OH, USA; Departments of Pharmacology, Molecular Biology and Microbiology, Biochemistry, and Proteomics and Bioinformatics, Case Western Reserve University School of Medicine, Cleveland, OH, USA; The CWRU-Cleveland VAMC Center for Antimicrobial Resistance and Epidemiology (Case VA CARES), Cleveland, OH, USA
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- Ibrahim, Emad Bashir (författare)
- Microbiology Division, Hamad Medical Corporation, Doha, Qatar
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- Jass, Jana, 1963- (författare)
- Örebro universitet,Institutionen för naturvetenskap och teknik
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- Omrani, Ali S. (författare)
- Communicable Diseases Center, Hamad Medical Corporation, Doha, Qatar
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(creator_code:org_t)
- 2019-09-03
- 2019
- Engelska.
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Ingår i: Journal of Antimicrobial Chemotherapy. - : Oxford University Press. - 0305-7453 .- 1460-2091. ; 74:12, s. 3497-3504
- Relaterad länk:
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https://www.ncbi.nlm...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
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- OBJECTIVES: To investigate the in vitro activity of ceftazidime/avibactam and ceftolozane/tazobactam against clinical isolates of MDR Pseudomonas aeruginosa from Qatar, as well as the mechanisms of resistance.METHODS: MDR P. aeruginosa isolated between October 2014 and September 2015 from all public hospitals in Qatar were included. The BD PhoenixTM system was used for identification and initial antimicrobial susceptibility testing, while Liofilchem MIC Test Strips (Liofilchem, Roseto degli Abruzzi, Italy) were used for confirmation of ceftazidime/avibactam and ceftolozane/tazobactam susceptibility. Ten ceftazidime/avibactam- and/or ceftolozane/tazobactam-resistant isolates were randomly selected for WGS.RESULTS: A total of 205 MDR P. aeruginosa isolates were included. Of these, 141 (68.8%) were susceptible to ceftazidime/avibactam, 129 (62.9%) were susceptible to ceftolozane/tazobactam, 121 (59.0%) were susceptible to both and 56 (27.3%) were susceptible to neither. Twenty (9.8%) isolates were susceptible to ceftazidime/avibactam but not to ceftolozane/tazobactam and only 8 (3.9%) were susceptible to ceftolozane/tazobactam but not to ceftazidime/avibactam. Less than 50% of XDR isolates were susceptible to ceftazidime/avibactam or ceftolozane/tazobactam. The 10 sequenced isolates belonged to six different STs and all produced AmpC and OXA enzymes; 5 (50%) produced ESBL and 4 (40%) produced VIM enzymes.CONCLUSIONS: MDR P. aeruginosa susceptibility rates to ceftazidime/avibactam and ceftolozane/tazobactam were higher than those to all existing antipseudomonal agents, except colistin, but were less than 50% in extremely resistant isolates. Non-susceptibility to ceftazidime/avibactam and ceftolozane/tazobactam was largely due to the production of ESBL and VIM enzymes. Ceftazidime/avibactam and ceftolozane/tazobactam are possible options for some patients with MDR P. aeruginosa in Qatar.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Infektionsmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Infectious Medicine (hsv//eng)
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Sid Ahmed, Mazen ...
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Abdel Hadi, Hama ...
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Hassan, Abubaker ...
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Abu Jarir, Sulie ...
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Al-Maslamani, Mu ...
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Eltai, Nahla Ome ...
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Dousa, Khalid M.
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Hujer, Andrea M.
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Sultan, Ali A.
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Söderquist, Bo, ...
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Bonomo, Robert A ...
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Ibrahim, Emad Ba ...
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Jass, Jana, 1963 ...
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Omrani, Ali S.
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