Sökning: id:"swepub:oai:DiVA.org:oru-81446" >
High risk of non-al...
High risk of non-alcoholic liver disease mortality in patients with chronic hepatitis C with illicit substance use disorder
-
- Kåberg, Martin (författare)
- Karolinska Institutet
-
- Larsson, Simon B. (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för infektionssjukdomar,Institute of Biomedicine, Department of Infectious Medicine
-
- Jerkeman, Anna (författare)
- Lund University,Lunds universitet,Klinisk infektionsmedicin,Forskargrupper vid Lunds universitet,Clinical infection medicine,Lund University Research Groups
-
visa fler...
-
- Nystedt, Anders (författare)
- Department of Translational Medicine, Section of Infectious Disease, Malmö, Lund University, Malmö, Sweden,Norrbotten County Council
-
- Duberg, Ann-Sofi, Docent, 1957- (författare)
- Örebro University,Örebro universitet,Institutionen för medicinska vetenskaper,Department of Infectious Diseases
-
- Kövamees, Jan (författare)
- AbbVie AB, Stockholm, Sweden
-
- Ydreborg, Magdalena, 1974 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för infektionssjukdomar,Institute of Biomedicine, Department of Infectious Medicine
-
- Aleman, Soo (författare)
- Karolinska Institutet
-
- Büsch, Katharina (författare)
- AbbVie AB, Stockholm, Sweden; Department of Laboratory Medicine, Division of Clinical Microbiology, Karolinska Institutet at Karolinska University Hospital, Huddinge, Stockholm, Sweden
-
- Alanko Blomé, Marianne (författare)
- Lund University,Lunds universitet,Klinisk infektionsmedicin,Forskargrupper vid Lunds universitet,Clinical infection medicine,Lund University Research Groups,Region Skåne
-
- Weiland, Ola (författare)
- Karolinska Institutet
-
- Söderholm, Jonas (författare)
- Karolinska Institutet
-
visa färre...
-
(creator_code:org_t)
- 2020-05-01
- 2020
- Engelska.
-
Ingår i: Scandinavian Journal of Gastroenterology. - : Taylor & Francis. - 0036-5521 .- 1502-7708. ; 55:5, s. 574-580
- Relaterad länk:
-
https://doi.org/10.1...
-
visa fler...
-
https://www.tandfonl...
-
http://dx.doi.org/10...
-
https://urn.kb.se/re...
-
https://doi.org/10.1...
-
https://lup.lub.lu.s...
-
http://kipublication...
-
https://gup.ub.gu.se...
-
visa färre...
Abstract
Ämnesord
Stäng
- Aims: Hepatitis C virus (HCV) is a slowly progressive disease, often transmitted among people who inject drugs (PWID). Mortality in PWID is high, with an overrepresentation of drug-related causes. This study investigated the risk of death in patients with chronic hepatitis C virus (HCV) infection with or without illicit substance use disorder (ISUD).Methods: Patients with HCV were identified using the Swedish National Patient Registry according to the International Classification of Diseases-10 (ICD-10) code B18.2, with ≤5 matched comparators from the general population. Patients with ≥2 physician visits with ICD-10 codes F11, F12, F14, F15, F16, or F19 were considered to have ISUD. The underlying cause of death was analyzed for alcoholic liver disease, non-alcoholic liver disease, liver cancer, drug-related and external causes, non-liver cancers, or other causes. Mortality risks were assessed using the standardized mortality ratio (SMR) with 95% CIs and Cox regression analyses for cause-specific hazard ratios.Results: In total, 38,186 patients with HCV were included, with 31% meeting the ISUD definition. Non-alcoholic liver disease SMRs in patients with and without ISUD were 123.2 (95% CI, 103.7-145.2) and 69.4 (95% CI, 63.8-75.3), respectively. The significant independent factors associated with non-alcoholic liver disease mortality were older age, being unmarried, male sex, and having ISUD.Conclusions: The relative risks for non-alcoholic liver disease mortality were elevated for patients with ISUD. Having ISUD was a significant independent factor for non-alcoholic liver disease. Thus, patients with HCV with ISUD should be given HCV treatment to reduce the risk for liver disease.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Gastroenterologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Gastroenterology and Hepatology (hsv//eng)
Nyckelord
- Hepatitis C
- chronic
- liver disease
- mortality
- substance abuse
- chronic
- Hepatitis C
- liver disease
- mortality
- substance abuse
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
-
Kåberg, Martin
-
Larsson, Simon B ...
-
Jerkeman, Anna
-
Nystedt, Anders
-
Duberg, Ann-Sofi ...
-
Kövamees, Jan
-
visa fler...
-
Ydreborg, Magdal ...
-
Aleman, Soo
-
Büsch, Katharina
-
Alanko Blomé, Ma ...
-
Weiland, Ola
-
Söderholm, Jonas
-
visa färre...
- Om ämnet
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Klinisk medicin
-
och Gastroenterologi
- Artiklar i publikationen
-
Scandinavian Jou ...
- Av lärosätet
-
Örebro universitet
-
Lunds universitet
-
Karolinska Institutet
-
Göteborgs universitet