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Differential effect...
Differential effects of left and right neuropathy on opioid gene expression in lumbar spinal cord
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- Kononenko, Olga (författare)
- Uppsala University,Uppsala universitet,Institutionen för farmaceutisk biovetenskap
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- Mityakina, Irina (författare)
- Moscow State University, Moscow, Russia,Moscow MV Lomonosov State Univ, Moscow, Russia.,Lomonosov Moscow State University
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- Galatenko, Vladimir (författare)
- Moscow State University, Moscow, Russia; University of Haifa, Haifa, Israel,Moscow MV Lomonosov State Univ, Moscow, Russia.;Univ Haifa, Tauber Bioinformat Res Ctr, Haifa, Israel.,Lomonosov Moscow State University
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- Watanabe, Hiroyuki (författare)
- Uppsala University,Uppsala universitet,Institutionen för farmaceutisk biovetenskap,.
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- Bazov, Igor, 1973- (författare)
- Uppsala University,Uppsala universitet,Institutionen för farmaceutisk biovetenskap
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- Gerashchenko, Anna (författare)
- Uppsala University,Uppsala universitet,Institutionen för farmaceutisk biovetenskap,Inst Mol Biol & Genet, Dept Mol Oncogenet, Kiev, Ukraine.,Institute of Molecular Biology and Genetics
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- Sarkisyan, Daniil (författare)
- Uppsala University,Uppsala universitet,Institutionen för farmaceutisk biovetenskap
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- Iatsyshyna, Anna (författare)
- Uppsala University,Uppsala universitet,Institutionen för farmaceutisk biovetenskap,Inst Mol Biol & Genet, Dept Human Genet, Kiev, Ukraine.,Institute of Molecular Biology and Genetics
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- Yakovleva, Tatiana (författare)
- Uppsala University,Uppsala universitet,Institutionen för farmaceutisk biovetenskap
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- Tonevitsky, Alex (författare)
- Moscow State University, Moscow, Russia; Higher School of Economics, Moscow, Russia,Moscow MV Lomonosov State Univ, Moscow, Russia.;Higher Sch Econ, Moscow, Russia.,Lomonosov Moscow State University,National Research University Higher School of Economics, Moscow
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- Marklund, Niklas (författare)
- Lund University,Lunds universitet,Neurokirurgi,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Neurosurgery,Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine,Skåne University Hospital
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- Ossipov, Michael H. (författare)
- University of Arizona Health Sciences Center, Tucson, United States,Univ Arizona, Hlth Sci Ctr, Dept Pharmacol, Tucson, AZ USA.
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- Bakalkin, Georgy (författare)
- Uppsala University,Uppsala universitet,Institutionen för farmaceutisk biovetenskap
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(creator_code:org_t)
- Elsevier, 2018
- 2018
- Engelska.
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Ingår i: Brain Research. - : Elsevier. - 0006-8993 .- 1872-6240. ; 1695, s. 78-83
- Relaterad länk:
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http://dx.doi.org/10...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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https://lup.lub.lu.s...
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Abstract
Ämnesord
Stäng
- The endogenous opioid system (EOS) controls the processing of nociceptive stimuli and is a pharmacological target for opioids. Alterations in expression of the EOS genes under neuropathic pain condition may account for low efficacy of opioid drugs. We here examined whether EOS expression patterns are altered in the lumbar spinal cord of the rats with spinal nerve ligation (SNL) as a neuropathic pain model. Effects of the left- and right-side SNL on expression of EOS genes in the ipsi- and contralateral spinal domains were analysed. The SNL-induced changes were complex and different between the genes; between the dorsal and ventral spinal domains; and between the left and right sides of the spinal cord. Prodynorphin (Pdyn) expression was upregulated in the ipsilateral dorsal domains by each the left and right-side SNL, while changes in expression of μ-opioid receptor (Oprm1) and proenkephalin (Penk) genes were dependent on the SNL side. Changes in expression of the Pdyn and κ-opioid receptor (Oprk1) genes were coordinated between the ipsi- and contralateral sides. Withdrawal response thresholds, indicators of mechanical allodynia correlated negatively with Pdyn expression in the right ventral domain after right side SNL. These findings suggest multiple roles of the EOS gene products in spinal sensitization and changes in motor reflexes, which may differ between the left and right sides.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Nyckelord
- Gene expression
- Lateralization
- Lumbar spinal cord
- Neuropathic pain
- Opioid system
- Rat model
- Gene expression
- Lateralization
- Lumbar spinal cord
- Neuropathic pain
- Opioid system
- Rat model
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
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Kononenko, Olga
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Mityakina, Irina
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Galatenko, Vladi ...
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Watanabe, Hiroyu ...
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Bazov, Igor, 197 ...
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Gerashchenko, An ...
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visa fler...
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Sarkisyan, Danii ...
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Iatsyshyna, Anna
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Yakovleva, Tatia ...
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Tonevitsky, Alex
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Marklund, Niklas
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Ossipov, Michael ...
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Bakalkin, Georgy
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- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Medicinska och f ...
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och Neurovetenskaper
- Artiklar i publikationen
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Brain Research
- Av lärosätet
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Örebro universitet
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Uppsala universitet
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Lunds universitet