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A New Retinal Detac...
A New Retinal Detachment Treatment Model for Evaluation of Vitreous Tamponades
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- Barth, Henrik (författare)
- Lund University,Lunds universitet,Translationell retinaforskning,Forskargrupper vid Lunds universitet,Biomimetic Retinal Tissue Engineering,Lund University Research Groups
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- Crafoord, Sven, 1950- (författare)
- Örebro universitet,Institutionen för medicinska vetenskaper,Department of Ophthalmology, Faculty of Medicine and Health, Örebro University Hospital , Örebro, Sweden
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- Ghosh, Fredrik (författare)
- Lund University,Lunds universitet,Oftalmologi, Lund,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Oftalmologi, Ghosh,Forskargrupper vid Lunds universitet,Ophthalmology, Lund,Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine,Oftalmology, Ghosh,Lund University Research Groups
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(creator_code:org_t)
- 2020-08-17
- 2021
- Engelska.
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Ingår i: Current Eye Research. - : Taylor & Francis. - 0271-3683 .- 1460-2202. ; 46:3, s. 373-379
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Abstract
Ämnesord
Stäng
- PURPOSE: To develop a treatment model of rhegmatogenous retinal detachment (RRD) in which the effects of various vitreous tamponades can be explored.METHODS: In a primary session, detachment was produced in the right eye of 24 rabbits using vitrectomy, posterior vitreous detachment, retinal break induction, and subretinal injection of viscoelastic solution. The following day, detachments were treated in 16 eyes using SF6 (n = 8) or Healaflow® (HF, a cross-linked hyaluronic acid hydrogel, n = 8) tamponade. Animals were followed for 1 month and thereafter examined macroscopically and morphologically in hematoxylin and eosin-stained sections.RESULTS: Retinal detachment (RD) was successfully treated using repeated surgery. Two HF eyes developed progressive vitritis and were excluded from further evaluation. Enlargement of the initial retinal rupture with concomitant RD was seen in 4/8 SF6 eyes, while all 6 HF eyes displayed an attached retina. Attached areas showed a normal retinal morphology except for in 1 HF eye with extensive degeneration.CONCLUSIONS: The RRD repeat vitrectomy model offers a possibility to explore the efficacy and complications of novel potential vitreous tamponades. Gel-based Healaflow® displays excellent anatomic reattachment, however, vitritis and retinal degeneration in some cases warrants further investigation.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Oftalmologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Ophthalmology (hsv//eng)
Nyckelord
- Histology
- hydrogel
- rabbit
- retinal detachment
- tamponade
- vitrectomy
- Histology
- hydrogel
- rabbit
- retinal detachment
- tamponade
- vitrectomy
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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