The Atlas of Inflammation Resolution (AIR)

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The Atlas of Inflammation Resolution (AIR)

Serhan, Charles N. (författare): Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA

Gupta, Shailendra K. (författare): Department of Systems Biology and Bioinformatics, University of Rostock, Rostock, Germany

Perretti, Mauro (författare): The William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, Charterhouse Square, London, UK

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Godson, Catherine (författare): Diabetes Complications Research Centre, Conway Institute & School of Medicine, University College Dublin, Belfield, Dublin, Ireland

Brennan, Eoin (författare): Diabetes Complications Research Centre, Conway Institute & School of Medicine, University College Dublin, Belfield, Dublin, Ireland

Li, Yongsheng (författare): Department of Medical Oncology, Chongqing University Cancer Hospital, Chongqing, 400030, China

Soehnlein, Oliver (författare): Karolinska Institutet

Shimizu, Takao (författare): Department of Lipidomics, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan; National Center for Global Health and Medicine, Toyama, Shinjuku-ku, Tokyo, Japan

Werz, Oliver (författare): Department of Pharmaceutical/Medicinal Chemistry, Institute of Pharmacy, Friedrich Schiller University Jena, Jena, Germany

Chiurchiù, Valerio (författare): Institute of Translational Pharmacology, National Research Council, Rome, Italy; Laboratory of Resolution of Neuroinflammation, IRCCS Santa Lucia Foundation, Rome, Italy

Azzi, Angelo (författare): School of Graduate Biomedical Pharmacology and Drug Development Program at Tufts University, Boston, MA, USA

Dubourdeau, Marc (författare): Ambiotis, Canal Biotech, Toulouse, France

Gupta, Suchi Smita (författare): Department of Systems Biology and Bioinformatics, University of Rostock, Rostock, Germany

Schopohl, Patrick (författare): Department of Systems Biology and Bioinformatics, University of Rostock, Rostock, Germany

Hoch, Matti (författare): Department of Systems Biology and Bioinformatics, University of Rostock, Rostock, Germany

Gjorgevikj, Dragana (författare): Department of Systems Biology and Bioinformatics, University of Rostock, Rostock, Germany

Khan, Faiz M. (författare): Department of Systems Biology and Bioinformatics, University of Rostock, Rostock, Germany

Brauer, David (författare): Department of Systems Biology and Bioinformatics, University of Rostock, Rostock, Germany

Tripathi, Anurag (författare): CSIR - Indian Institute of Toxicology Research, Lucknow, India

Cesnulevicius, Konstantin (författare): Department of Medical Affairs & Research, Heel GmbH, Baden-Baden, Germany

Lescheid, David (författare): Department of Medical Affairs & Research, Heel GmbH, Baden-Baden, Germany

Schultz, Myron (författare): Department of Medical Affairs & Research, Heel GmbH, Baden-Baden, Germany

Särndahl, Eva, 1963- (författare): Örebro universitet,Institutionen för medicinska vetenskaper,IRiSC - Inflammatory Response and Infection Susceptibility Centre

Repsilber, Dirk, 1971- (författare): Örebro universitet,Institutionen för medicinska vetenskaper

Kruse, Robert, 1972- (författare): Örebro universitet,Institutionen för medicinska vetenskaper,Department of Clinical Research Laboratory,IRiSC - Inflammatory Response and Infection Susceptibility Centre

Sala, Angelo (författare): Department of Pharmaceutical Sciences, University of Milan, Milano, and IRIB, C.N.R, Palermo, Italy

Haeggström, Jesper Z. (författare): Karolinska Institutet

Levy, Bruce D. (författare): Brigham and Women's Hospital, Department of Medicine, Pulmonary and Critical Care Medicine and Harvard Medical School, Boston, MA, USA

Filep, János G. (författare): Department of Pathology and Cell Biology, University of Montreal, Research Center, Maisonneuve-Rosemont Hospital, Montreal, Canada

Wolkenhauer, Olaf (författare): Department of Systems Biology and Bioinformatics, University of Rostock, Rostock, Germany; Stellenbosch Institute for Advanced Study (STIAS), Wallenberg Research Centre at Stellenbosch University, Stellenbosch, South Africa

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Elsevier, 2020
2020
Engelska.
Ingår i: Molecular Aspects of Medicine. - : Elsevier. - 0098-2997 .- 1872-9452. ; 74

Relaterad länk:: https://doi.org/10.1...; visa fler...; https://doi.org/10.1...; https://urn.kb.se/re...; https://doi.org/10.1...; http://kipublication...; visa färre...

Tidskriftsartikel (refereegranskat)

Abstract Ämnesord

Stäng

Acute inflammation is a protective reaction by the immune system in response to invading pathogens or tissue damage. Ideally, the response should be localized, self-limited, and returning to homeostasis. If not resolved, acute inflammation can result in organ pathologies leading to chronic inflammatory phenotypes. Acute inflammation and inflammation resolution are complex coordinated processes, involving a number of cell types, interacting in space and time. The biomolecular complexity and the fact that several biomedical fields are involved, make a multi- and interdisciplinary approach necessary. The Atlas of Inflammation Resolution (AIR) is a web-based resource capturing an essential part of the state-of-the-art in acute inflammation and inflammation resolution research. The AIR provides an interface for users to search thousands of interactions, arranged in inter-connected multi-layers of process diagrams, covering a wide range of clinically relevant phenotypes. By mapping experimental data onto the AIR, it can be used to elucidate drug action as well as molecular mechanisms underlying different disease phenotypes. For the visualization and exploration of information, the AIR uses the Minerva platform, which is a well-established tool for the presentation of disease maps. The molecular details of the AIR are encoded using international standards. The AIR was created as a freely accessible resource, supporting research and education in the fields of acute inflammation and inflammation resolution. The AIR connects research communities, facilitates clinical decision making, and supports research scientists in the formulation and validation of hypotheses. The AIR is accessible through https://air.bio.informatik.uni-rostock.de.

Ämnesord

NATURVETENSKAP -- Data- och informationsvetenskap -- Datavetenskap (hsv//swe)
NATURAL SCIENCES -- Computer and Information Sciences -- Computer Sciences (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP -- Medicinsk bioteknologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Medical Biotechnology (hsv//eng)

Nyckelord

Acute inflammation
Disease map
Inflammation resolution
Inflammatory mediators
Molecular interaction map
Molecular switches
Pro-resolving mediators
Systems biology

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NATURVETENSKAP: NATURVETENSKAP; och Data och informa ...; och Datavetenskap

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Av lärosätet: Örebro universitet; Karolinska Institutet

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